There are numerous herbs growing in India, some are cultivated and others are growing wild, among these herbs is well known name Garlic (Allium sativum L.) which is cultivated and consumed almost across the globe. People use Garlic as a spice / pickles. Garlic contains medicinally active compounds like Alliin/Allicin, Di-allyl Disulfide, 2-vinyl-4H-1, 3-dithiin, Ajoene. Alliin /Allicin is chole...

Bacterial infections of cutaneous leishmaniasis cause skin ulcers on mice, resulting in increased tissue deterioration, and these infections can be controlled with liquid allicin. To isolate and identify the incidences of real secondary bacterial infections in mice, we performed the current study by injecting mice (n = 50) with Leishmania major. L. major infections were initiated by an intramus...

BACKGROUND Artesunate, extracted from Artemisia annua, has been proven to have anti-cancer potential. Allicin, diallyl thiosulfinate, the main biologically active compound derived from garlic, is also of interest in cancer treatment research. This object of this report was to document synergistic effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo. METH...

Bulbous Allium spp. such as “big-headed” elephant garlic (Allium ampeloprasum L.) and common sativus contain a wide range of bioactive compounds with health-promoting properties are most commonly used food seasonings. The objective the present study is to verify if there difference in selected nutraceuticals (dry matter, TPC, allicin) elemental profiles (macro- micro-elements) two species produ...

overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. in this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

Objective(s): To illuminate the functional effects of allicin on rats with cognitive deficits induced by tunicamycin (TM) and the molecular mechanism of this process. Materials and Methods: 200–250 g male SD rats were divided into three groups at random: control group (n=12), TM group (5 μl, 50 μM, i.c.v, n=12), and allicin treatment group (180 mg/kg/d with chow diet, n=12). After 16 weeks of a...

Abstract: Objectives: To explore the effects of allicin on expression mitochondrial autophagyrelated proteins in liver tissues hepatic fibrosis (HF) rats. Materials and Methods: 45 SD rats were randomly divided into Normal, Model, Low, Middle High groups. The HF rat model was replicated intraperitoneal injection carbon tetrachloride ethanol gavage for 4 weeks. Detection alanine aminotransferase...

Background/Aim: Alzheimer's disease is a progressive disorder that causes atrophy and neuronal death in the brain. Currently, there not any effective therapy for disease. The current research was designed to investigate beneficial effects of allicin on Alzheimer’s SHSY-5Y cells vitro elucidating neuroprotective mechanism allicin. Methods: Human neuroblastoma cell line (SH-SY5Y) differentiated w...

A combination of crushed garlic (Allium sativum sativum) has been used as a traditional remedy for antimicrobial testing suggested that the mixture of tw antimicrobial effects on both Staphylococcus aureu Analyses of the extract of garlic and black cumin by G confirmed that the main components of garlic were allic allicin transformed products such as diallyldisulfide a black cumin were thymoqui...

  Background and Objective: The management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. In the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line HT29 as an apoptosis resistant cell line, i...