cDNAs of fibrinogen A alpha and gamma chains were individually subcloned into a eukaryotic expression vector by using the polymerase chain reaction. Triple cotransfection into COS cells of the two plasmids together with a B beta chain expression plasmid, constructed as described previously (Danishefsky, K.J., Hartwig, R., Banerjee, D., and Redman, C. (1990) Biochim. Biophys. Acta 1048, 202-208)...

PURPOSE The aim of this investigation was to exploit lens-specific glycated crystallins as an immunogen to detect human glycated crystallins and their circulating autoantibodies in human serum during aging in relation to the development of cataract. METHODS Polyclonal antibodies were produced against human total lens proteins (40-80 years) in rabbits. The specificity of the antibodies produce...

We develop a general formalism to study the three-point correlation functions of conserved higher-spin supercurrent multiplets J α ( r ) ̇ $J_{\alpha (r) \dot{\alpha }(r)}$ in 4D N = 1 ${\cal N}=1$ superconformal theory. All constraints imposed by symmetry on function ⟨ β 2 γ 3 ⟩ $\langle J_{\alpha (r_1) }(r_1)} J_{\beta (r_2) \dot{\beta }(r_2) }J_{\gamma (r_3) \dot{\gamma }(r_3)}\rangle$ are sy...

Interferon-gamma is produced by immune cells before MS exacerbations, and exogenous IFN-gamma treatment causes MS attacks. IFN-beta production, conversely, rises after exacerbations. IFN-beta therapy ameliorates MS, possibly by lowering IFN-gamma secretion and inhibiting responses to IFN-gamma. IFN-gamma effects are regulated by IFN-gamma receptor (IFNGR) expression. IFN-gamma is pro-inflammato...

To determine whether hemoglobin regulation is normal in diseases affecting beta-globin gene expression, globin synthesis was examined in members of a family of a patient with hereditary persistence of fetal hemoglobin/beta o-thalassemia (HPFH/beta o-thal). The HPFH defect is the Ghanian type II, with a deletion from psi beta 1 to at least 20 kb 3' to beta. The beta o-thal gene has the haplotype...

We give the necessary and sufficient conditions for weighted inequality \begin{document}$ \begin{equation*} \||x|^{-b} T_{{\alpha}_{1}, \dots, {\alpha}_{m}, {\beta}_{1}, {\beta}_{m}, {\gamma}_{1}, {\gamma}_{m}}f \|_{L^q(\mathbb{R}^{n})} \leq C \||x|^{a} f\|_{L^p(\mathbb{R}^{n})} \end{equation*} $\end{document} both inside outside scaling regime of singular operator$ {\gamma}_{m}}f(x): = \int_{\...

An important challenge is to understand the functional specialization of dynein heavy chains. The ciliary outer arm dynein from Tetrahymena thermophila is a heterotrimer of three heavy chains, called alpha, beta and gamma. In order to dissect the contributions of the individual heavy chains, we used controlled urea treatment to dissociate Tetrahymena outer arm dynein into a 19S beta/gamma dimer...