Our laboratory has developed a method of particle exposure whereby anesthetized rats intratracheally inhale, at a regulated breathing rate and pressure, an aerosolized test material. This method is capable of delivering considerable doses in a short time period and, unlike the commonly used method of intratracheal instillation, does so with an even particle distribution throughout the lung. Ear...

In the environment, living organisms are exposed to a mixture of stressors, and the combined effects are deemed as multiple stressor effects. In the present work, the authors studied the multiple stressor effect in embryos of the zebrafish (Danio rerio) from simultaneous exposure to alpha particles and depleted uranium (DU) through quantification of apoptotic signals at 24 h post-fertilisation ...

Interactions between alveolar macrophages (AMs) and epithelial cells may promote inflammatory responses to air pollution particles. Normal rat AMs, the alveolar type II epithelial cell line RLE-6TN (RLE), or cocultures of both cell types were incubated with various particles (0-50 microg/ml) for 24 h, followed by assay of released TNF-alpha and MIP-2. The particles used included titanium dioxid...

OBJECTIVE To test the hypothesis whether determination of high-density lipoprotein (HDL) subpopulations provides more power to predict recurrent cardiovascular disease (CVD) events (nonfatal myocardial infarction, coronary heart disease death, and stroke) than traditional risk factors in the Veterans Affairs HDL Intervention Trial (VA-HIT). METHODS AND RESULTS Apolipoprotein A-I (apoA-I)-cont...

ZnS nanoparticles (NPs) doped with ‎Ag‎, ‎Cu‎, ‎and AgCu were synthesized using hydrothermal‎ ‎method in water solution‎. ‎The NPS are characterized by X-ray diffraction (XRD)‎, ‎energy-dispersive‎ ‎X-ray spectroscopy scanning (EDX)‎, ‎scanning electron‎ ‎microscopy (SEM) and dynamic light scattering (DLS)‎. ‎The produced NPs have approximately hexagonal structure and a cubic zinc blended struc...