objectives: the purpose of this study was to explore the general health status in women as care givers of the elderly people with alzheimer who attending to the iranian association of alzheimer’s disease. methods & materials: in this descriptive –cross sectional study as a introductory stage of a randomized controlled field trial, 150 women were recruited with a consecutive sampling method. the...

BACKGROUND Alzheimer disease is an increasingly common condition in older people. Knowledge of life expectancy after the diagnosis of Alzheimer disease and of associations of patient characteristics with survival may help planning for future care. OBJECTIVE To investigate the course of Alzheimer disease after initial diagnosis and examine associations hypothesized to correlate with survival a...

Risk factors for developing Alzheimer disease include hypercholesterolemia, hypertension, obesity, and diabetes. Due to lack of effective treatments for Alzheimer disease, nutrition and primary prevention becomes important.

BACKGROUND Alzheimer disease is characterized by cognitive decline, senile plaques of β-amyloid (Aβ) peptides, neurofibrillary tangles composed of hyperphosphorylated τ proteins and neuronal loss. Aβ and τ are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are serine-threonine protein kinases activated by phosphorylation and involved in neuronal death. METHOD...

(a) The types of population vary enormously in parameters such as place of residence (e.g. community versus hospital-based samples) and age range (as dementia is much more common in the very elderly, a sample stratified towards the upper age ranges will contain numerically more cases). (b) The diagnostic procedures vary, some involve personal examination by trained staff, others rely on second-...

Alzheimer disease is characterized by cerebral Abeta deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Abeta-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These da...

To date, nearly 35.6 million people world wide live with dementia, and the situation is going to get worse by 2050 with 115.4 million cases.(1) In the western world, the prevalence for dementia in people over the age of 60 is greater than 5% and two thirds are due to Alzheimer disease,(2) (-) (5) the most common form of dementias.   Alzheimer disease (AD), first described as "presenile dementi...

As neurons age, their survival depends on eliminating a growing burden of damaged, potentially toxic proteins and organelles-a capability that declines owing to aging and disease factors. Here, we review the two proteolytic systems principally responsible for protein quality control in neurons and their important contributions to Alzheimer disease pathogenesis. In the first section, the discove...

---------------------------------------------------------------------***--------------------------------------------------------------------Abstract Alzheimer’s disease is most common cause of dementia and involves a progressive degeneration of the cerebral cortex. It is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. In Alzheimer disease death of the br...