The conjugated homobimetallic palladium(II) complex [(L1)Pd(qd)Pd(L1)] (qd = quinonediimine) was obtained in a one-pot reaction by the in-situ oxidative complexation of 1,4-phenylenediamine with the palladium(II) complex [(L1)Pd(MeCN)] (H2L1 = N,N'-bis(2-phenylethyl)-2,6-pyridinedicarboxamide) while in the absence of an additional ligand [(L1)Pd(MeCN)] was converted to the amide-bridged macrocy...

An emissive terbium complex has been conjugated to a C12 chain, Lys-Arg7, Arg7, a tetraguanidinium cation and human serum albumin; two-photon excitation at 720 nm facilitated microscopy studies revealing cell localisation profiles with the oligo-guanidinium conjugate localising in mitochondria but causing apoptotic cell death (IC(50)12 microM), the C12-amide complex giving rise to necrotic cell...

amide-iminol tautomerism was studied for ionized oxamic acid (oa+•) in the gas phase using thedft method with the ub3lyp functional and various basis sets {6-31++g(d,p), 6-311+g(d,p), and augcc-pvdz}. among twenty tautomers-rotamers possible for oa+•, eleven isomers were found to bethermodynamically stable. similarly as for the neutral molecule, ionization (oa → oa+• + e) favors theamidization ...

five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of n-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in n-methyl-2-pyrrolidone (nmp) and pyridine at solution containingdissolved cacl2. all of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dl/g. the r...

The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10 to 100 μM. Methyl fenbufen amide had significant cytotoxic effects at a concentration of 100 μM. As the length of the alkyl amide side chain in...

Attractive interactions between two carboxamide groups in a "stacked" geometry are explored under isolated molecule conditions. Infrared spectra of single conformations of a small gamma-peptide, Ac-gamma(2)-hPhe-NHMe, reveal the presence of a conformation in which the two amide planes are approximately parallel with the amide dipoles in an antialigned orientation. This stacked conformation is e...

A series of NNO ketoimines bearing trifluoromethyl substituents were synthesized from the Schiff base condensation of 1,3-diketones (1,1,1-trifluoro-5,5-dimethyl-2,4-hexanedione, 4,4,4-trifluoro-1-phenyl-1,3-butanedione, and 1,1,1-trifluoro-2,4-pentanedione, 1,1,1,5,5,5-hexafluoroacetylacetone) and 8-aminoquinoline or 8-amino-2-methylquinoline and isolated in 40-70% yield. The ketoimines were c...