Aromatic L-amino acid decarboxylase (AADC) is required for the synthesis of the neurotransmitters dopamine and serotonin. Children with defects in the AADC gene show compromised development, particularly in motor function. Drug therapy has only marginal effects on some of the symptoms and does not change early childhood mortality. Here, we performed adeno-associated viral vector-mediated gene t...

Cancer is caused by uncontrollable growth of neoplastic cells, leading to invasion of adjacent and distant tissues resulting in death. Cancer cells have specific nutrient(s) auxotrophy and have a much higher nutrient demand compared to normal tissues. Therefore, different metabolic inhibitors or nutrient-depleting enzymes have been tested for their anti-cancer activities. We review recent avail...

These experiments were conducted to determine metabolizable energy and amino acid digestibilities of soybean meal, sunflower meal and canola meal in broiler chickens by using titanium oxide as indigestible marker in intact or caecectomized cockerels. Ileal and total tract digestibility of amino acids were measured using broiler chickens, moreover, digestibility were also determined in the intac...

the oil and protein content of three varieties of water melon seeds namely, chillian black, dixy queen and charlston gray were determined. the soluble proteins were studied and measured by paper chromatography and amino acid analyzer. the results indicated that oil content of the seeds was 43, 53 and 45% and protein content was 27, 23, and 34% respectively. the soluble proteins contained all th...

BACKGROUND A substantial proportion of hepatitis C virus (HCV)-1b infected patients do not response to pegylated interferon-α plus ribavirin (PegIFNα/RBV) combination therapy that was partially associated with mutations in the non-structural 5A (NS5A) protein. OBJECTIVES Analysis of NS5A polymorphisms in HCV genotype 1b pre-treatment serum samples from Estonian patients and their effect on th...

The mortality of burn patients remains high in spite of the advances made in treating initial burn shock, controlling burn wound infection, and providing nutritional support. Smoke inhalation is recognized as a strong determinant of morbidity and mortality in burn patients, and most burn patients die because of associated inhalation injury. There are many reports on this combined injury (cutane...

Human immunodeficiency virus type 1 (HIV-1) amino acid substitutions observed during antiretroviral drug therapy may be caused by drug selection, non-drug-related evolution, or sampling error introduced by the sequencing process. We analyzed HIV-1 sequences from 371 untreated patients and from 178 patients receiving a single protease inhibitor. Amino acid substitution patterns during treatment ...