6-Nitro- and 6-amino-benzothiazoles bearing different chains in position 2 and their corresponding anthranilic acid derivatives were investigated for their in vitro antiparasitic properties against parasites of the species Leishmania infantum and Trichomonas vaginalis compared to their toxicity towards human monocytes. Biological investigations established that the antiprotozoal properties depe...

Two experiments were conducted to examine the effect of benzoic acid in the diet of lactating sows on urinary pH and nutrient digestibility. In the first experiment, three levels of benzoic acid in the diet were tested (0.5, 1.0, and 2.0%), while in the second experiment only one dietary level of benzoic acid (0.5%) was used. In the second experiment, the urinary excretion of benzoic acid and h...

Para-Aminobenzoic acid is supported on silica gel via reaction of activated silica gel and p-aminobenzoic acid which is then converted to its manganese and cobalt salts. A mixture of the manganese and cobalt salts of the acid is used to catalyze allylic and benzylic alcohols to their corresponding carbonyl compounds in reasonable yields using oxygen or air. Reactions are clean and the catal...

OBJECTIVES Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. MATERIALS AND METHODS In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-a...

1. The contribution of dietary constituents to the large urinary output of benzoic acid characteristic of ruminants and some herbivores is not well understood. 2. Methods for the analysis of quinic, cyclohexanecarboxylic, benzoic, phenylacetic, 3-phenylpropionic and cinnamic acids in urine and in rumen fluids were developed. 3. The urinary output of aromatic acids by sheep given seven-rations w...

The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...

The infrared spectra of benzoic acid and deuterobenzoic acid embedded in Ar matrices were obtained. The only benzoic acid conformer with syn position of O-H and C=O groups was found to fix in the matrices. We have demonstrated that both a raise of benzoic acid concentration and a matrix annealing lead to formation of H-bonded benzoic acid dimers. The results of semiempirical AM1 calculations al...

A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.