Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare neurometabolic disorder characterized by defective degradation of gamma-aminobutyric acid (GABA), major inhibitory neurotransmitter the brain. Children with SSADH present motor mental delay, intractable seizures, infantile onset hypotonia, speech disturbances, extrapyramidal symptoms and ataxia. This wide spectrum results from inc...

Background and purpose Executive function impairment, a slight but noticeable cognitive deficit in mild impairment (MCI) patients, is influenced by gamma-aminobutyric acid (GABA) levels. Reduced accompanied thinning of the cerebral cortex, which has higher GABA levels than white matter. However, relationships among levels, cortical thickness, executive MCI patients have not yet been elucidated....

background preliminary studies revealed that 4-aminobutyric acid (gaba) is a key and major inhibitory neurotransmitter in the brain. evidence from many animal studies and even some clinical studies indicate that gaba is responsible for regulating behavior and also plays an important role in brain functions. previous studies presented glutamic acid decarboxylase as a catalyst for the conversion ...

The neutral amino acid gamma-aminobutyric acid (GABA) produced membrane hyperpolarization and increased membrane chloride ion conductance of spinal cord (SC) and cortical (CTX) neurons in cell culture. GABA dose-response curves were obtained for SC neurons by pressure applying known concentrations of GABA from micropipettes with large tips (miniperfusion pipettes). GABA response threshold was a...

The physiological and biochemical role of the ?-aminobutyric acid (GABA) shunt pathway in green pea seedlings (Pisum sativum L.) was studied response to soil water holding capacity levels: 80%, 60%, 40%, 20%, 10% grown under continuous light at 25 °C for 7 days 14 days, separately. Characterization seeds germination pattern, growth (plant height, fresh dry weight, chlorophyll contents), GABA me...

Tomatoes are rich in secondary metabolites such as lycopene, ?-carotene, phenolics, flavonoids, and vitamin C, which responsible for their antioxidant activates. A high level of ?-Aminobutyric acid (GABA), a health-promoting functional compound, was also found to accumulate tomato fruit. In addition the internal quality attributes, acceptance fruit by consumers is highly dependent on appearance...

The effect of calcium silicate, γ-aminobutyric acid (GABA), and their mixture on the adaptation wheat corn to simulated rain has been evaluated in pot experiments. Acid was by watering twice with distilled water acidified sulfuric pH = 2. Test plants were grown a plant growth chamber under controlled conditions temperature, illumination relative humidity for 18 days. physiological state test as...

The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.

The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated mala...

Gamma-aminobutyric acid (GABA) metabolism was studied in rats chronically exposed to 2.86 GHz microwaves at an incident power level of 10 mW/cm or acutely exposed to incident power levels of 40 or 80 mW/cm. No changes occurred in whole brain GABA levels or L-glutamic decarboxylase activity following these exposures. These results suggest that an altered GABA metabolism is not involved in report...