The excellent results obtained in this trial indicate that tinidazole is a drug worthy of extensive evaluation in the treatment of amoebiasis, as three single daily doses is a simple form of treatment. The drug was well tolerated and free from any toxic effects.

Leaves of Codiaeum variegatum ("garden croton") are used against bloody diarrhoea by local populations in Cameroon. This study aims to search for the active components from C. variegatum against Entamoeba histolytica, and thereby initiate the study of their mechanism of action. A bioassay-guided screening of the aqueous extracts from C. variegatum leaves and various fractions was carried out ag...

Interactions of pathogenic Entamoeba histolytica (HM 1) with human intestinal epithelial cells (Henle-407) were investigated. The E. histolytica trophozoites adhered and cytolysed 87% of cultured epithelial cell monolayers. A significant (P less than 0.001) inhibition of cytopathic effect of amoebic trophozoites pretreated with monoclonal antibodies to a 29 kDa surface associated protein sugges...

A 41-year-old male was admitted to the hospital with symptoms of diarrhea, fever and rapidly progressive respiratory distress. A chest radiograph and computed tomography (CT) of the chest and the abdomen showed a large amount of right pleural effusion and a large liver abscess. The patient was thus diagnosed to have amoebic colitis, amoebic liver abscess and amoebic empyema complicated with an ...

OBJECTIVE : To assess the role of Indirect Haemagglutination Test for the diagnosis of amoebic liver abscess. STUDY DESIGN : Comparative Study PLACE AND DURATION : This study was carried out at Basic medical Sciences Institute, JPMC, Karachi from February 2000 to January 2001. SUBJECTS AND METHODS : Blood samples were obtained from 100 cases of amoebic liver abscess and 100 age matched healthy ...

A 38 year old gentleman presented with fever and right hypochondrial pain. On further evaluation he was detected to have an amoebic liver abscess (ALA) in the right lobe of the liver. The abscess yielded anchovy sauce pus on percutaneous drainage. Following the percutaneous drainage the patient developed tachycardia. Electrocardiogram revealed atrial flutter with rapid ventricular rate and ST e...

The macrophage-derived mediator tumor necrosis factor alpha (TNF) is a cytokine with pleiotropic effects. TNF exhibits potent immunologic and inflammatory properties in parasitic diseases. The present study examined the production of TNF by macrophages isolated from gerbils infected with Entamoeba histolytica and by naive macrophages in response to amoebae in vitro. Amoebic liver abscess-derive...

The examinations here recorded were made in the field during the East African campaign. They were undertaken to determine the percentage of carriers of Entamoeba histolytica among a particular set of native porters. It had been noticed that amoebic dysentery in East Africa was much less common than bacillary among troops of all nationalities and porters, but that its incidence varied in differe...

Campylobacter enteritis, giardiasis, legionnaires' disease, primary amoebic meningoencephalitis, and the viral haemorrhagic fevers are among the "new" diseases. In hospitals group B streptococcal infections have been recognised, there have been episodes of hospital-acquired enterovirus infections, and developments in surgical prostheses and immunosuppression have been followed by the appearance...