Dogs with compensated biventricular hypertrophy due to chronic atrioventricular block (cAVB), are more susceptible to develop drug-induced Torsade-de-Pointes arrhythmias and sudden cardiac death. It has been suggested that the increased Na(+) influx in hypertrophied cAVB ventricular myocytes contribute to these lethal arrhythmias. The increased Na(+) influx was not mediated by Na(+) channels, i...

Copper and arsenic underwent large changes in chemical form during the development and senescence of natural phytoplankton blooms in the Patuxent River, a subestuary ofChesapeake Bay in Maryland. Arsenate was rapidly reduced to arsenite and methylated species. At a total arsenic concentration of 20 nmollI , arsenate reduction rates ranged from 50 amol cellI d -I to > 230 amol cellI d -I, with t...

10.1517/14622416.6.4.439 © 2 For years we have recognized that using genetics to target the right medicines to the right patients at the right time could improve healthcare; however, technical and financial constraints have prevented researchers from conducting the comprehensive, whole-genome association studies required to make such advances. Now, Perlegen and its collaborators are making pers...

The nonsteroidal anti-inflammatory drug (NSAID) sulindac prevents experimental colon cancer and can regress precancerous polyps in humans. Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis. Given the known role of mitogen-activated protein kinase (MAPK) in signal transduction and th...

conclusions we confirm that in amol city and surrounding areas, the prevalence of true hcv infection is 0.05%, which is lower than that previously reported from iran. results the mean age of participants was 42.70 ± 17.10 years. of these participants, 57.2% (n = 3483) were male. anti-hcv antibody was positive in 12 individuals from which five were riba positive. three of these subjects were pcr...

This is a delightful book, and in some ways an alarming one. It deals with the special entertainment films for children, produced by Mary Field for the J. Arthur Rank Organisation between 1944 and 1950. She called the book "Good Company", because her aim was to see that for a few hours each week, children should have an opportunity of "intimacy with good example", believing that "the friends yo...

To test the hypothesis that changes in the expression of the glucocorticoid receptor (GCR) and the beta(2)-adrenoceptor (beta(2)-AR) contribute significantly to the abnormal glucose metabolism in skeletal muscle from patients with Type II diabetes, we have examined (1) the levels of total GCR (alpha+beta isoforms), the alpha/alpha 2 isoform of GCR and beta(2)-AR mRNAs in skeletal muscle from in...