نتایج جستجو برای: amplification factor
تعداد نتایج: 895445 فیلتر نتایج به سال:
The helical resonator is a scheme for the production of high voltage at radio frequency, useful gas breakdown and plasma sustainment, which, through proper design, enables avoiding use matching network. In this work, we consider treatment resonator, including grounded shield, as transmission line with shorted end an open one, latter possibly connected to capacitive load. input applied tap point...
MET is a driver oncogene in non-small-cell lung cancer (NSCLC), and its amplification is associated with acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. A 56-year-old Japanese male with lung adenocarcinoma harboring an EGFR exon 21 L858R mutation received erlotinib to which he responded for 12 months. After disease progression, re-biopsy analyses revea...
We study the capture of dark matter particles by neutron stars in close binary systems. By performing a direct numerical simulation, we find that there is a sizable amplification of the rate of dark matter capture by each of the companions. In the case of the binary pulsar PSR J1906+0746 with the orbital period of 4 hours the amplification factor is approximately equal to 3.5. This amplificatio...
In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driv...
Purpose: FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic potential of AZD4547, a potent and selective ATPcompetitive receptor tyrosine kinase inhibitor of fibroblast growth factor receptor (FGFR)1–3, in patients with FGFR2-amplified gastric cancer. Experimental Design: Array-comparative genomi...
BACKGROUND AND AIMS Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to multi-kinase inhibitors targeting FGFR1. Esophageal cancer is an aggressive disease, for which novel targeted therapies are highly warranted. METHODS This study was designed to investigate the prevalence and clinical significance of FGFR1 amplification in a tissue microarray...
A capacitance equivalence method to determine the amplification factor of 'triodes with irregular geometry was proposed by O'Neill. This ,method I does not intrinsically take into its purview the presence of support rods of appreciable radius. In a previous communication, the author derived the :equicapacitance structure for elliptic grids using a method based on O'Neill's principle. In this pa...
Various gene amplifications have been observed in gliomas. Prognostic-genomic correlations testing simultaneously all these amplified genes have never been conducted in anaplastic oligodendrogliomas. A set of 38 genes that have been reported to be amplified in gliomas and investigated as the main targets of amplicons were studied in a series of 52 anaplastic oligodendrogliomas using bacterial a...
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