It has been proved that kindling model of amygdala is sensitive to estradiol because the latter accelerates the overall rate of kindling. However the effect of estrogen on the seizure process has not been investigated. In this study fully kindled male rats were treated with different doses (10, 30, and 50 µg/kg, i.p.) of estradiol benzoate (EB) daily and such kindling parameters as seizure stag...

epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. it has been shown that each seizure has a depressing effect on the following seizure. thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. in this study, the role of adenosine a1 receptors in pos...

 Introduction: Neural stimulation is a promising new technology for the treatment of medically-intractable seizures.  Transcranial Magnetic Stimulation (TMS) is a simple, non-invasive, low cost technique which is widely used in neurophysiology. In a few studies that have been performed at different frequencies the therapeutic effects of this technique were not obvious. Repetition of low frequen...

BACKGROUND Intracerebral infusion of anticonvulsant agent secreting cells has proven to raise the threshold for seizure generation in epileptogenic areas. Median ganglionic eminence (MGE) is the main embryonic region where future GABAergic cells originate. Here we report the results of intraamygdaline grafting of MGE cells versus fibroblasts in a piriform cortex kindling model of epilepsy in th...