Visual interpretation is considered the gold standard for amyloid scans in clinical practice. However, dichotomous classification of deposition by visual reading always results bias due to rater experience. Therefore, there a need more lenient and flexible amyloid-equivocal A total 461 participants were included this study. Amyloid glucose positron-emission tomography was performed, neuropsycho...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

BACKGROUND C-Reactive protein (CRP) and serum amyloid A protein (SAA) are exquisitely sensitive acute-phase reactants, but their baseline values are surprisingly constant in individuals in the general population. These values, especially of CRP, are associated with future atherothrombotic events, and the determinants of baseline CRP and SAA concentration are therefore of considerable interest. ...

Alzheimer’s disease (AD) is a neurodegenerative disease that is the most common type of dementia.AD includes 60_80% of dementia and most people with AD have more than 65 years old.AD causes losing neuronal activity by abnormal proteins. Plaques of beta-amyloid and tangles of “tau” protein can lead to AD. Recently evidence has found that AD may come from outside of central nerv...

amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different organs, where it usually causes some type of dysfunction. its cause is unknown. five different types of amyloidosis have been described according to the underlying disease; immunoglobulin amyloidosis, familial amyloidosis, senile systemic amyloidosis, secondary amyloidosis and hemodialysis-associated am...

BACKGROUND Vitamin A deficiency adversely affects child morbidity and survival. This deficiency is estimated by measurement of plasma retinol concentrations, but because plasma retinol is reduced by clinical and subclinical infection, this proxy measure can lead to overestimation. Infection and trauma are accompanied by rises in concentrations of acute-phase proteins in plasma. We aimed to esti...

Platelet aggregation beta amyloid main causes inflammation of neurons in Alzheimer’s disease. In fact, creating this inflammation due to inappropriate actions in blood brain barrier (BBB) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. The only thing that can be done to prevent and reduce pro-inflammatory factors such as cyto...

progressive cognitive decline is one of the hallmark symptoms of alzheimer’s disease (ad) which can be modeled by β-amyloid injection into specific regions of brain. since epigallocatechin-3-gallate (egcg) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether egcg administration protects against β-am...

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...