neurological inflammatory diseases are developing rapidly. different factors involved in the pathogenesis of these diseases. in this article, we discuss some of the mechanisms are dealt with. an aberrant procedure of beta-amyloid precursor protein (bapp) to form neurotoxic beta-amyloid peptides and an accumulated insoluble polymer of beta –amyloid (ba) that forms the senile plaque. the above pr...

timolol is a non-selective beta-adrenergic receptor antagonist administered for treating glaucoma, heart attacks and hypertension. in the present study, we set out to determine whether or not timolol can provoke cataract formation, thus the influence of timolol on the amyloid-type aggregation of crystallin was investigated. we then provided experimental evidence of crystallin aggregation and it...

the objective of this study was to evaluate the concentration of these acute phase proteins(serum amyloid a, milk amyloid a and serum haptoglobin) and alteration in hematological values in some inflammatory diseases in dairy cattle. fifty-six holstein dairy cows with some inflammatory diseases were used in this study including: subclinical mastitis, hematological infections (theileriosis and an...

Energy disaggregation is the task of estimating power consumption of each individual appliance from the whole-house electric signals. In this paper, we study this task based on deep learning methods which have achieved a lot of success in various domains recently. We introduce the feature extraction method that uses multiple parallel convolutional layers of varying filter sizes and present an L...

molecular chaperones or amyloid-binding compounds?  perspective on their application as possible therapeutic agents in reduction of cytotoxicity of amyloid oligomers

Escherichia coli caseinolytic protease (Clp)B is a hexameric AAA+ [expanded superfamily of AAA (ATPase associated with various cellular activities)] enzyme that has the unique ability to catalyse protein disaggregation. Such enzymes are essential for proteome maintenance. Based on structural comparisons to homologous enzymes involved in ATP-dependent proteolysis and clever protein engineering s...

A linear time-varying aggregate traffic flow model can be used to develop Traffic Flow Management strategies based on optimization algorithms. However, there are no methods available in the literature to translate these aggregate solutions into actions involving individual aircraft. This paper describes and implements a computationally efficient disaggregation algorithm, which converts an aggre...