Objective: To gain a better understanding of how iron accumulates in human rheumatoid synovium. Methods: The distribution of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium was investigated by immunocytochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Both heav...

PURPOSE Molecular analysis of complex phenomena, such as selective death of photoreceptors and their rescue by neuro-protective agents, has been hindered by limitations of techniques for investigating gene expression in individual cells within a heterogeneous tissue such as the retina. The purpose of this study was to develop methods to assess gene expression in single retinal cells. METHODS ...

OBJECTIVE To gain a better understanding of how iron accumulates in human rheumatoid synovium. METHODS The distribution of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium was investigated by immunocytochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS Both hea...

A young adult male patient presented with diffuse hair loss of two years duration. Clinical features and investigations were suggestive of loose anagen hair syndrome. He developed alopecia totalis during follow-up. Scalp biopsy revealed perifollicular lymphocytic infiltration. A diagnosis of adult-onset loose anagen hair syndrome with alopecia areata was made. Introduction Loose anagen hair syn...

We demonstrate the presence and hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors (CRF-R) in C57BL/6 mouse skin. To correlate this with a physiological, developmentally controlled tissue remodeling process, we have analyzed CRF and CRF-R expression during defined stages of the murine hair cycle with its rhythmic changes between growth (anagen), regression...

Natural plant extracts have been reported as potential therapy for hair loss treatments by normalizing Wnt/β-catenin signaling pathway. A Cinchona succirubra extract targets pathway regulation and stimulates, in association with Caffeine, the expression of Syndecan-1 involved anchoring. These effects were confirmed vivo an anti-hair serum combining both ingredients. The vitro efficacy Caffeine ...

Hair follicles (HFs) undergo cycles of growth (anagen), regression (catagen) and relative quiescence (telogen), whose timing velocity are controlled by the “hair cycle clock (HCC)”, an intrinsic autonomous oscillator system molecular nature remains to be elucidated. In this study, we have further explored hypothesis that Myelin Protein Zero-like 3 (MPZL3), a nuclear-encoded protein localized mi...