Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were deve...

Propylthiouracil (PTU) is known to be a potential cause of antineutrophil cytoplasmic antibody (ANCA) positive small vessel vasculitis, resulting in glomerulonephritis and diffuse alveolar hemorrhage (DAH). Herein, we describe a 25-year-old pregnant woman who developed a perinulcear ANCA (p-ANCA) and myeloperoxidase ANCA (MPO-ANCA) positive DAH during PTU therapy. The patient improved after cor...

conclusions the diagnosis of thrombocytosis is not easy in all cases. the coexistence of anca and the immune complex in cgn may cause a severe inflammatory state, leading to extreme rt. the roles that the immune complex and anca play on the effect of the platelet count and function in cgn need further research. introduction we describe a female patient with extreme reactive thrombocytosis (rt) ...

introduction antineutrophil cytoplasmic antibodies (anca)-associated glomerulonephritis (gn) is characterized by necrotizing and crescentic gn with paucity of immunoglobulin (ig) and complement deposition, which is also known as pauci-immune crescentic gn. membranous nephropathy (mn) is characterized by the formation of subepithelial immune deposit with resultant changes in glomerular basement ...

infection and the development of MPO-ANCA-associated GN, we compared the titres of C. pneumoniae abs in the active and remission phase of the disease in the same patients. The titres of anti-C. pneumoniae IgM and IgA, but not IgG abs in ANCA (remission) group significantly decreased compared with that in ANCA (active) [IgM ab: 1.22 0.47 vs 1.05 0.49U, P< 0.05; IgA ab: 1.70 1.20 vs 1.29 0.88 U, ...

Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoantibodies (autoAbs) to GBM and dsDNA enables early diagnosis and appropriate treatment of RPGN ai...

BACKGROUND The "International consensus statement on testing and reporting antineutrophil cytoplasmic antibodies (ANCA)" advocates screening by indirect immunofluorescence (IIF), but external quality assessment programmes often demonstrate different IIF patterns for a single serum. AIM To determine whether the variation in IIF patterns can be attributed solely to errors in interpretation. M...

PURPOSE We report the case of a 59-year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis (IE). An elevated proteinase-3 (PR3)-ANCA and pauci-immune glomerulonephritis (GN) on renal biopsy were discovered, corresponding to ANCA-mediated GN. We conducted a literature review to assess the role of ANCA in IE and tr...

BACKGROUND AND OBJECTIVES Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The authors report the clinical and pathologic findings in 14 patients with MGN and ANCA-associated NCGN. RESULTS The cohort...

The prevalence of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against myeloperoxidase (MPO) in pauci-immune necrotizing crescentic glomerulonephritis (NCGN) is dependent on the assay(s) used. We investigated the frequency of MPO-ANCA as detected by different assays for MPO-ANCA in a large cohort of patients with biopsy-proven pauci-immune NCGN. Sera from 121 consecutive untreated pat...