The effects of histones on the enzymatic phosphorylation of nuclear phosphoproteins have been extensively studied in vitro. Histones cause a 5to Io-fold increase in the rate and extent of phosphorylation of nuclear phosphoprotein, with the lysinerich histones being the most effective at stimulation. Evidence suggests that the histones are not being phosphorylated themselves, but rather act to m...

Abstract Operative time is a potential modifiable target for reducing cost and optimizing efficiency in total hip arthroplasty (THA). Shorter operative times are associated with decreased costs complications. One proposed solution operating room (OR) to preferentially perform THAs at higher volume center. The purpose of this study investigate the impact different hospital settings on mean THA. ...

The Qu’Appelle Valley drainage system provides water to a third of the population of the Canadian Great Plains, yet is plagued by poor water quality, excess plant growth, and periodic fish kills. Fossil algae (diatoms, pigments) and invertebrates (chironomids) in Pasqua Lake were analyzed by variance partitioning analysis (VPA) to determine the relative importance of climate, resource use, and ...

compounds from South American medicinal plants, we became interested in medicinal plants belonging to the genus Maytenus (Celastraceae). The plants of this genus are widely used in folk medicine in South America and are rich sources of terpenoids including dihydro-b-agarofuran sesquiterpenes, highly oxidized friedelane triterpenes, and several types of triterpene dimers. Among these, triterpene...

BACKGROUND Coxofemoral osteoarthritis is a chronic, disabling condition affecting people and dogs, with THA providing an excellent return to function in severely affected joints. The principal role of THA is to restore an adequate range of motion to the hip joint while transferring load from the acetabulum in order to improve the survival of the implant and enhance the limb function in the shor...

OBJECTIVE The study hypotheses were that: (i) there would be a difference in sagittal plane alignment between patients with symptomatic osteoarthritis of the hip and those with lumbar degenerative disk disease; and (ii) that sagittal plane lumbar alignment would change following total hip arthroplasty (THA). METHODS In this prospective study, a series of patients without back pain or lumbar c...

Total hip arthroplasty (THA) is one of the most reliable procedures that can provide shortterm high clinical success rates and long-term durable outcome. The surgery has been developed for more than 40 years and most of the clinical practices are standardized for the patient care. In the past, THA had been done by making a wound about 25 cm in length. Many surgeons believed that big wounds shou...

Abstract Background Of late, periarticular analgesic injection (PAI) has become a common alternative treatment for pain following total hip arthroplasty (THA). However, the systemic effects of PAI containing corticosteroids in patients subjected to THA have not been investigated. This study evaluated efficacy and corticosteroid THA. Methods single-center, retrospective cohort enrolled undergoin...

Tacrine (THA), used in the treatment of Alzheimer's disease, is known to induce hepatotoxicity, the mechanisms of which remain to be fully established. We have previously shown that THA reduced intracellular glutathione concentration in rat hepatocytes in primary culture, thus pointing to a possible role for oxidative stress in THA toxicity. To test this, the effects of antioxidant molecules, n...

BACKGROUND Rotational acetabular osteotomy (RAO) is an effective joint-preserving surgical treatment for adulthood hip dysplasia (AHD). Despite sufficient correction of acetabular dysplasia, some patients still experience osteoarthritis (OA) progression and require total hip arthroplasty (THA). The purposes of the current study were to investigate the survival rate and the risk factors for OA p...