BACKGROUND & OBJECTIVES A large number of plants have been recognized to be effective in the treatment of diabetes mellitus. Persistent hyperglycaemia is associated with decreased function of immune system and cerebral ischaemia mainly due to increased oxidative stress and inflammatory response. Andrographis paniculata is a medicinal plant widely used in folk medicine for various purposes. In t...

The stability of andrographolide, the major active diterpene lactone from Andrographis paniculata (BURM. f.) WALL. ex NEES., was determined to show that, while crystalline andrographolide was highly stable even at 70 degrees C (75% relative humidity) over a period of 3 months, its amorphous phase degraded promptly. Heat-accelerated conditions revealed second-order kinetics of the decomposition ...

Andrographolde is the major secondary metabolite from the plant Andrographis paniculata. It has been found to show cytotoxic activity. To improve the efficacy on cytotoxic activity, a series of new sulfonyl derivatives have been synthesized by structural modifications of the andrographolide at C-2 position. All the derivatives were tested for their cytotoxic activity against human small lung ca...

In vitro antibacterial and antifungal activity of the chloroform extracts of the root and the stem of Andrographis paniculata at different concentrations were screened against gram positive bacteria Staphylococcus aureus, Bacillus subtilis, gram negative bacteria Escherichia coli, Proteus vulgaris and fungi Aspergillus niger, Penicillium chrysogenum by cup plate method. The extracts were found ...

BACKGROUND The anti-inflammatory activity of Andrographis paniculata (Acanthaceae), a traditional medicine widely used in Asia, is commonly attributed to andrographolide, its main secondary metabolite. Commercial A. paniculata extracts are standardised to andrographolide content. We undertook the present study to investigate 1) how selective enrichment of andrographolide in commercial A. panicu...

INTRODUCTION Antimicrobial resistance (AMR) is a substantial threat to public health. Safe and effective alternatives are required to reduce unnecessary antibiotic prescribing. Andrographis Paniculata (A. Paniculata, Chuān Xīn Lián) has traditionally been used in Indian and Chinese herbal medicine for cough, cold and influenza, suggesting a role in respiratory tract infections (RTIs). This syst...