Anti-angiogenesis is the therapeutic strategy designed to disrupt vascular supply and starve tumors of nutrients oxygen. This achieved mainly by blocking endothelial growth factor (VEGF) actions, as VEGF signaling pathway considered main angiogenesis promoter active in tumor microenvironment (TME) under hypoxic conditions. A total 16 anti-angiogenic agents, including anti-VEGF antibodies, recep...

Angiogenesis is a vital process resulting in the formation of new blood vessels. It is normally a highly regulated process that occurs during human development, reproduction, and wound repair. However, angiogenesis can also become a fundamental pathogenic process found in cancer and several other diseases. To date, the inhibition of angiogenesis has been researched at both the bench and the bed...

Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in several preclinical models. The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor (VEGF) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2-negative and COX-2-positive tumors. VE...

Colorectal cancer (CRC) is the third most common cancer worldwide and accounts for 10% of all new cancer diagnoses. Angiogenesis is a tightly regulated process that is mediated by a group of angiogenic factors such as vascular endothelial growth factor and its receptors. Given the widespread use of antiangiogenic agents in CRC, there has been considerable interest in the development of methods ...

Angiogenesis inhibitors cause increased hypoxia in tumors and this results in the induction of cytoprotective autophagy. Targeting this adaptation using autophagy inhibitors can overcome resistance to antiangiogenic therapy and enhance the antitumor effects.

Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development. Angiogenesis inhibitors are now being tested in pediatric populations whereas inhibitors of vasculogenesis are in an earl...

Vascular basement membrane (VBM) derived molecules are regulators of certain biological activities such as cell growth, differentiation and angiogenesis. Angiogenesis is regulated by a systematic controlled balance between VBM derived antiangiogenic factors and proangiogenic growth factors. In the normal physiological state, equilibrium is maintained between the antiangiogenic and proangiogenic...

1. Abstract 2. Introduction 3. The process of angiogenesis and its experimental models 4. Angiogenic mediators in the rheumatoid synovium 4.1. Heparin-binding growth factors 4.2. Other non-heparin binding growth factors 4.3. Cytokines 4.4. Chemokines and chemokine receptors 4.5. Extracellular matrix components and matrix-degrading proteolytic enzymes 4.6. Cellular adhesion molecules 4.7. Other ...

angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. using angiogenesis inhibitors, therefore, is one of the ways for cancer treatment and prevention of metastasis. medicinal plants have been shown to play a major role in the treatment of a variety of cancers. in this direction, cytotoxic and angiogenic effects of oleo gum resi...