1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

The angiotensin I-converting enzyme (ACE) converts the inactive angiotensin I molecule to the active angiotensin II. ACE is rich in epithelium, endothelium, and neuroepithelial cells and it found largely on the brush border of intestine and kidney proximal tubules. ACE also presents in the serum. Some pulmonary and renal toxic drugs change the serum and tissue ACE contents. In this research ACE...

Ang II plays an important role in the pathophysiology of cardiovascular disease. Angiotensin-converting enzyme (ACE) inhibitors lower Ang II levels by inhibiting conversion of Ang I to Ang II, but Ang II levels have been shown to return to normal with chronic ACE inhibitor treatment. In this issue of the JCI, Wei et al. show that ACE inhibition induces an increase in chymase activity in cardiac...

Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAM...

The purpose of these investigations was to determine whether the aminopeptidase B and leucine aminopeptidase inhibitor bestatin, the chymase inhibitor chymostatin, the calpain inhibitor E-64, and the neutral serine protease inhibitor leupeptin affect the angiotensin converting enzyme (ACE) activity in T-lymphocytes. ACE activity in homogenates of T-lymphocytes or in intact T-lymphocytes in susp...

Cardiovascular remodeling is a major mechanism leading to adverse outcome. The renin-angiotensin-aldosterone system (RAAS), with angiotensin II as its primary effector peptide, plays an important regulatory role in cardiovascular remodeling. Most angiotensin II is formed via the angiotensin-converting enzyme (ACE) pathway, providing rationale for use of ACE inhibitors. Hypertension and myocardi...

Penetration of coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the cause COVID-19 pandemic, into cells requires interaction surface spike S protein virus with extracellular domain membrane-bound form angiotensin-converting enzyme type 2 (ACE2). This enzyme, key component renin-angiotensin system, is responsible for synthesis angiotensin-(1–7), which has vasodilator and...