نتایج جستجو برای: animal testing alternatives
تعداد نتایج: 580515 فیلتر نتایج به سال:
The consistency approach for release testing of established vaccines promotes the use of in vitro, analytical, non-animal based systems allowing the monitoring of quality parameters during the whole production process. By using highly sensitive non-animal methods, the consistency approach has the potential to improve the quality of testing and to foster the 3Rs (replacement, refinement and redu...
delegates, including scientists and students, and six laureates participated in the event. For the first time, a plenary session on alternative methods entitled Animal Alternatives in Teaching and Testing was held at the ISC. Interest in alternatives has been spurred by the success of the Mahatma Gandhi-Doerenkamp Center (MGDC) for Alternatives to Use of Animals in life Science education , esta...
Concerns of traditional prenatal aneuploidy testing methods, such as low accuracy of noninvasive and health risks associated with invasive procedures, were overcome with the introduction of novel noninvasive methods based on genetics (NIPT). These were rapidly adopted into clinical practice in many countries after a series of successful trials of various independent submethods. Here we present ...
Clopidogrel is a thienopyridine that irreversibly inhibits platelet P2Y12 receptors and adenosine diphosphate (ADP) mediated platelet aggregation. It is a prodrug that requires activation in the liver by cytochrome P450 enzymes (CYP3A4, CYP3A5, CYP1A2, CYP2C9, CYP2C19, and/or CYP2B6) . Dual antiplatelet therapy with clopidogrel and aspirin has become the mainstay of treatment of patients with a...
Aluminum-based metal matrix composite (MMC) materials are used in the design of ground transportation vehicles and aircraft. Compared with conventional, unreinforced alloys, composite materials usually exhibit higher strength, both at ambient and elevated temperatures, as well as good fatigue strength and wear resistance. MMCs could be produced by variety of methods such as Stir cast, Liquid In...
The U.S. National Institute for Occupational Safety and Health (NIOSH) has been researching refuge alternatives (RAs) since 2007. RAs typically have built-in pressure relief valves (PRVs) to prevent the unit from reaching unsafe pressures. The U.S. Mine Safety and Health Administration requires that these valves vent the chamber at a maximum pressure of 1.25 kPa (0.18 psi, 5.0 in. H2O), or as s...
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