OBJECTIVES Bufonis venonum (BV) is the dried white secretions of the auricular and skin glands of the toads Bufo bufo gargarizans or Bufo melanosticus Schneider. This study was performed to evaluate the toxicity of intramuscularly- administered Bufonis venonum pharmacopuncture (BVP) and to calculate its approximate lethality through a single-dose test with Sprague-Dawley (SD) rats. METHODS Tw...

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

in order to investigate effects of partial replacement of starch with neutral detergent soluble fiber (ndsf) on weekly weight gain, feed intake, feed conversion ratio, digestibility and some histopathological changes of rumen, 16 lambs were used in completely randomized design. the experimental period was 70 days. dietary treatments were 1- control (high starch), 2- beet pulp, 18 percent, 3- be...

background: the main aim of the present study was to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in caput and cauda epididymis of mice. materials and methods: aflatoxin was obtained by growing aspergillus parasiticus in sucrose - magnesium sulphate - potassium nitrate - yeast extract (smky) liquid medium. pure curcumin (97% purity) was purchased from hi-media labor...

background & objectives: streptozotocin (stz) is used for induction of type-1 diabetes mellitus in animal models. its beta-cytotoxic action results in sudden release of insulin leading to severe hypoglycaemia and even mortality. however, its sensitivity varies with species. present investigation was aimed at studying stz induced acute clinical effects in rabbits. methods: streptozotocin@ 65...

While many studies have shown that maternal weight and nutrition in pregnancy affects offspring's breast cancer risk, no studies have investigated the impact of paternal body weight on daughters' risk of this disease. Here, we show that diet-induced paternal overweight around the time of conception can epigenetically reprogram father's germ-line and modulate their daughters' birth weight and li...

Chronic toxicity test was conducted for 28 days with post larval stages of Penaeus indicus to arsenic for studying the changes associated with growth pattern, specifying the length, weight and condition factor. Arsenic exposures produced significant (P < 0.05) effect in terms of length, weight and deteriorated the condition factor of the test animal. Differentiation in relation between the cond...