The effects and interaction between cAMP-analogue dibutyryl-cAMP and calmodulin antagonists were investigated on de novo synthesis and secretion of lipids in cultures of hepatoma McArdle-RH7777 cells and normal rat hepatocytes. Dibutyryl cAMP caused a significant decrease in the secretion of de novo synthesized triacyl [3H] glycerol in both cultures of McArdle cells and rat hepatocytes. The ...

The effects and interaction between cAMP-analogue dibutyryl-cAMP and calmodulin antagonists were investigated on de novo synthesis and secretion of lipids in cultures of hepatoma McArdle-RH7777 cells and normal rat hepatocytes. Dibutyryl cAMP caused a significant decrease in the secretion of de novo synthesized triacyl [3H] glycerol in both cultures of McArdle cells and rat hepatocytes. The ...

Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovasc...

Obesity and tobacco abuse, widely recognised as serious health hazards, are increasing in prevalence. Obesity is associated with numerous metabolic complications such as dyslipidemia, type 2 diabetes and cardiovascular diseases. Smoking is a high risk factor for hypertension, lung carcinoma and various other health related problems. The agents that have been used for the treatment of obesity in...

Background The decreased mortality rate obtained with antiretrovirals (ARVs) induced a shift of HIV infection toward a chronic condition and increased the fraction of patients aged >50years. Senior patients can be included in three subgroups with different clinical problems. Long term exposure to ARVs give rise to the main clinical problems. Several studies recognize age as an independent risk ...