Lamson et al. (1-8) carried out extensive studies on the anthelmintic activity of a large number of alkylhydroxybenzenes and found that substances which apparently act through the cuticle of ascaris were ineffective when their melting points were too high. Harwood (9) demonstrated that if such chemicals were kept in the liquid phase by adulteration with certain organic liquids, their in vitro a...

In order to develop a better bioactive molecules with good efficacy, we synthesized a new series of Thiazolo [3,2-a] pyrimidine derivatives with good yield and studied their anthelmintic properties, structureactivity relationships (SARs). A new series of Thiazolo[3,2-a]pyrimidines have been synthesized through duff formylation, ‘One pot’ Biginelli reaction, cyclization followed by knoevenagel c...

A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng, South Africa, from January to March 2006. In the herds belonging to twelve smallholder sheep farmers, the efficacies of albendazole, levamisole and closantel were tested by faecal egg count reduction tests where 80 % efficacy was considered the cut off f...

BACKGROUND Helminth parasites cause untold morbidity and mortality to billions of people and livestock. Anthelmintic drugs are available but resistance is a problem in livestock parasites, and is a looming threat for human helminths. Testing the efficacy of available anthelmintic drugs and development of new drugs is hindered by the lack of objective high-throughput screening methods. Currently...

BACKGROUND Fasciolosis due to Fasciola hepatica is the most important hepatic disease in veterinary medicine. Its relevance is important because of the major economical losses to the cattle industry such as: reduction in milk, meat and wool production; miscarriages, anemia, liver condemnation and occasionally deaths, are estimated in billons of dollars. The emergence of fluke resistance due to ...

The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode isoform of an evolutionary conserved Ca2+-activated K+ channel, SLO-1. To test this at the molec...

We evaluated the profitability of anthelmintic treatment and nutritional supplements using partial budget analysis on 108 weaned Menz (n=39), 50% Awassi-Menz (n=38) and 75% Awassi-Menz (n=31) crossbred sheep genotypes kept on-station under subclinical helminthosis at Debre Berhan, Ethiopia. Data were collected on feed intake, live weight, eggs per gram of faeces (EPG), packed cell volume (PCV),...

South America has a large population of small ruminants. Currents estimates are approximately 100 million sheep and 23 million goats. A large percentage of these flocks are raised in the humid tropics/sub-tropics. Nematode parasitism is singly the most important disease of these animals and typically farmers resort to frequent anthelmintic treatment in attempts to control this problem. Because ...

Introduction: The perennial herb Phyllanthus niruri, belonging to the family Euphorbiaceae is commonly known as Bhuiavala in Marathi and possess antibacterial, analgesic, antipyretic, anti-hepatotoxic, antifungal and anthelmintic activity. Objective: The present study was carried out to validate the in vitro anthelmintic activity of hot aqueous whole plant extract of Phyllanthus niruri against ...

The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previouslyisolated from the fruits of Annona squamosa (sugar-apples), is described via coupling oftetrapeptide l-prolyl-l-tyrosyl-l-leucyl-l-proline methyl ester with tripeptide Boc-glycyl-lvalyl-l-proline followed by cyclization of the linear fragment having seven amino acid units.Structure of the synthesized cycl...