The bas is of the effects of urea on the human skin is its penetration kinetics into different skin layers. A strong vehicle dependence can be estabilished. Therefore wide differences are found in the duration and intensity of increased water-binding capacity after application of different urea containing emulsions. For therapy to increase the hydration and water-binding capacity in the homy la...

The precise causes of psoriasis, a chronic skin disorder characterized by hyperproliferation of keratinocytes and incomplete keratinization, are unclear. It is known that expression of helix-loop-helix transcription factor Id1, which functions as an inhibitor of differentiation, is upregulated in psoriatic skin. We investigated the effect of the antipsoriatic drug dithranol on mRNA and protein ...

The aim of this contribution is the application of matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) in the area of photolithographic structuring. As proof of concept, this method was used to image an UV exposed negative photoresist layer, which is generally used to manufacture printed circuit boards (PCB) for electronic components. The negative photoresist laye...

A simple, specific, accurate, precise and reproducible method has been developed and validated for the estimation of Dithranol in lipid nanoparticle by RP-HPLC method. RP-HPLC estimation of dithranol in prepared formulation was performed using Phenomenex ODS 5μ, C18 column and Acetonitrile: Methanol: Buffer (20:20:60) as mobile phase which had shown sharp peak when detected at 258 nm. The linea...

Dithranol was introduced into anti-psoriatic therapy in 1916, but the principle of its activity remains unkown with regard to the quantitative aspects of its efficacy e.g. in enzyme inhibition, D N A interaction and interference with lipid metabolism. In vitro experiments have indicated that dithranol irreversibly inhibits glucose-6-phosphate-dehydrogenase (EC 1.1.1.49) [10] and the incorporati...

The binding of [20-3H]phorbol 12,13-dibutyrate ([3H]PDB) to intact living epidermal cells in monolayer culture was characterized. At 37 degrees C, the maximum specific [3H]PDB binding (binding displaceable by 30 microM unlabeled PDB) was attained in 15--20 min and was followed by a rapid decrease (down regulation) of radioactivity bound to the cells. The activity lost by the cells during this d...

The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrop...

marketing data collection from treated patients. This is being conducted in the U.S.A. by the various companies involved in biological immune modulators. Further information will undoubtedly become available over the next several years. The recent warnings from the manufacturers of infliximab (Remicade ) about the threefold increased risk of lymphoma and leukaemia in patients with rheumatoid ar...

The effects of selected tumor-promoting agents and their nonpromoting analogs on DNA repair synthesis were examined in human diploid fibroblasts (WI-38) damaged with N-acetoxy-2-acetylaminofluorene. Over a range of doses, three promoters (croton oil, 12-O-tetradecanoyl phorbol13-acetate, and anthralin) were found to inhibit DNA repair synthesis while their nonpromoting analogs (phorbol and 1,8-...