The investigations of Starr (1) demonstrated that Xunthomonas pruni requires an exogenous source of nicotinic acid when grown on a medium containing vitamin-free, acid-hydrolyzed casein, methionine, or glutamic acid to provide an organic form of nitrogen. Preliminary work in this laboratory showed that tryptophan could replace nicotinic acid for growth in a similar medium. This was the first kn...

It has been known that a variety of non-steroidal anti-inflammatory drugs uncouple oxidative phosphorylation in mitochondria (1-5). Adams and Cobb (2) have studied whether or not the inhibition of inflammation by non-steroidal drugs was related to their in vitro capacity to uncouple oxidative phosphorylation. Whitehouse (6) has made an extensive survey on this problem. We have reported that...

We examined how molecular structure of 24 anthranilate and benzoic acid derivatives correlated with drinking behavior in European starlings Sturnus vulgaris. The effectiveness of bird repellents was associated with basicity, the presence of an electron-donating group in resonance with an electron-withdrawing carboxylic group on a phenyl ring, and a heterocyclic ring in the same pi cloud plane a...

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures...

ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several compounds milk. The vitro and vivo interactions between tryptophan-related ABCG2 were investigated. tryptophan metabolome was determined by liquid chromatography-tandem mass spectrometry milk plasma from wild-type Abcg2?/? mice as well dairy cows carrying Y581S polymorphism (Y/S) noncarrier animals (Y/Y). milk-t...

Abstract Development of latent prints employing cyanoacrylate ester (CA) can be a multistep process including CA fuming and subsequent fluorescent staining to produce fingerprints sufficient contrast for comparison work. To enable single‐step fuming—staining process, selection fluorophores have been developed as sublimation dyes in fuming. A greater array such luminescent would allow users flex...

The in vivo regulation of intermediate reactions in the pathway of tryptophan synthesis in Neurospora crassa was examined in a double mutant (tr-2, tr-3) which lacks the functions of the first and last enzymes in the pathway from chorismic acid to tryptophan. The double mutant can convert anthranilic acid to indole and indole-3-glycerol, and the production of these indolyl compounds by germinat...

Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester conne...