Epilepsy affects 5 to 10 per 1000 of the general population. It is the third most common neurological disorder after stroke and Alzheimer's disease. Available anti-convulsant drugs effectively control epilepsy in about 50% of the patients. Many epileptic seizures are refractory to current anti-epileptic drugs and safety of the anti-epileptic drugs has always been a concern. Herbal drugs may ser...

OBJECTIVE Electroencephalographic status epilepticus occurs in 9-35% of comatose patients after cardiac arrest. Mortality is 90-100%. It is unclear whether (some) seizure patterns represent a condition in which anti-epileptic treatment may improve outcome, or severe ischemic damage, in which treatment is futile. We explored current treatment practice and its effect on patients' outcome. METHO...

Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AE...

First drugs which were largely used for chemotherapeutically and preventive use were the sulfonamides. Sulfonamides have a wide range of pharmacological activities such as against rheumatoid arthritis, anti-hypertensive, anti-epileptic, anti-bacterial, anti-protozoal, anti-fungal, non-peptidic vasopressin receptor antagonists, antiinflammatory, and translation initiation inhibitors. These sulfo...

Use of medication with a desired effect on the central nervous system (as with anti-epileptic drugs) in children will undoubtedly cause concern about neurodevelopment. Data are emerging to suggest an effect of anticonvulsants on the developing brain of the unborn child when administered to mothers with epilepsy. This obviously requires detailed evaluation, especially when considering the risks ...

Abstract Background and objective Phenobarbitone is used as a first-line drug for neonatal seizures. However, its poor short- long-term safety profile concerning. We aim to systematically synthesize the data on efficacy of phenobarbitone agent compare it against other anti-epileptic drugs (AEDs) in neonates. Methods Using keywords related study population (neonatal seizure) intervention (phenob...

OBJECTIVE To report and discuss twelve cases of Valproate (VPA) induced hyperammonaemic encephalopathy without liver failure in subjects receiving VPA therapy. METHODS This study was conducted in the department of Neurology, G.B. Pant Hospital, New Delhi from January 2000 to December 2006. The subjects were on treatment with VPA alone or in combination with other anti epileptic drugs and deve...