Human immunodeficiency virus (HIV) is a causative agent of acquired immune deficiency syndrome (AIDS). Highly active antiretroviral therapy (HAART) can slow down the replication of HIV-1, leading to an improvement in the survival of HIV-1-infected patients. However, drug toxicities and poor drug administration has led to the emergence of a drug-resistant strain. HIV-1 immunotherapy has been con...

phytochemical investigation of the aerial parts of euphorbia erythradenia bioss. (euphorbiaceae), one of iranian endemic euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using nmr and mass techniques. anti hiv...

BACKGROUND Seeking and utilisation of HIV prevention, treatment, care, and support services for people living with HIV is often hampered by HIV-related stigma. The study aimed to explore the perceptions and experiences regarding treatment, care, and support amongst people living with HIV in Viet Nam, where the HIV epidemic is concentrated among injecting drug users, sex workers, and men who hav...

background hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are among the most important health issues in turkey. human immunodeficiency virus (hiv) infections are less frequently observed in the country. the individuals who had blood transfusions, patients undergoing hemodialysis, and intravenous drug addicted individuals, people who had tattoos/piercings, communal living environ...

background and objectives: toxoplasmosis has become one of the more frequent opportunistic infections and the most common cause of focal brain lesions complicating the course of aids. however, there is a little information about the frequency of the toxoplasmosis in various regions of iran. at the present study, we evaluated the prevalence of toxoplasmosis in patients with aids in mashhasd (nor...

Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies, taking advantage the ability acid group form multiple hydrogen bonds. The target compounds synthesi...

disseminated tuberculosis (tb) is commonly seen in hiv-infected patients and is major cause of death in these patients. in hiv-infected patients disseminated tuberculosis is frequently undiagnosed or misdiagnosed. in this article we report a case of disseminated tb in a hiv-infected patient with a relatively long history of fever and other complaints without definite diagnosis. diagnosis of dis...

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C, were isolated from Schisandra micrantha; micrandilactone C exhibited an EC50 value of 7.71 microg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of make it a promising lead for therapeutic development ...

optimal reduction in blood pressure with antihypertensive agents helps to prevent microvascular and macrovascular complications of diabetes. the objective of the study was to evaluate the current utilization pattern of antihypertensive medications among patients with diabetes and coexistent hypertension as per the jnc seventh report guidelines. a cross-sectional survey was conducted among patie...

background : drug injection is one of the most significant risk factors for viral hepatitis and human immunodeficiency virus (hiv) infection. the present study was performed to evaluate the frequency of hepatitis b (hbv) and hiv infection in idus and to identify the risk factors of these infections in this group in a central city of iran, shahre-kord. methods : this study was conducted in 2004 ...