Paclitaxel is an anti-microtubule agent, most widely used chemotherapeutic agent for the treatment of malignant solid tumors. However, it associated with some severe side effects including painful neurotoxicity reporting neuropathic pain and sensory abnormalities by patients during after paclitaxel therapy. Peripheral neuropathy was induced administration (4 mg/kg on days 1, 3, 5, 7). In this s...

objective: asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. to test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of crocus sativus (c. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. materials and methods: to induce experimental asthma, rat...

Selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) as well as acetaminophen belong to the most widely prescribed therapeutic agents worldwide. Their efficacy in pain relief notwithstanding, the use of NSAIDs is associated with an increased cardiovascular risk, which can be partly attributed to their blood pressure raising potential. Adequately powered placebo-controlled ...

Teucrium polium, a medicinal plant that belongs to the family Labiatae is widely used in folk medicine as antidiabetic, antibactrial and anti-inflammatory agent. In this study, we evaluated the effect of Teucrium polium on the mouse polymorphonuclear neutrophils. The animals were divided into five groups including four test and one control group, which orally received 50 and 100 mg/kg of aqueou...

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used of all therapeutic agents. Although they are effective analgesics they do have significant adverse side-effects. Before treatment is started the prescriber should always weigh efficacy against possible side-effects. NSAIDs vary in their selectivity for inhibiting the two types of cyclo-oxygenase. An NSAID should there...

Abstract Acne vulgaris is a common disease of the pilosebaceous unit. Hyperseborrhea, follicular colonization by Cutibacterium acnes and complex inflammatory state are pathogenic factors acne vulgaris. In present study we investigated anti-acne efficacy Castanea crenata bur extract (CBE) in vitro searched active compound for mitigating hyperseborrhea. sebocytes, CBE inhibited sebum synthesis th...

Osteoarthritis is a substantial burden for patients with the disease. The known medications disease target mitigation of disease’s symptoms. So, drug development management osteoarthritis represents an important challenge in medical field. This work based on new benzofuran–pyrazole–pyridine-based compound 8 potential anti-inflammatory and anti-osteoarthritis properties. Microanalytical spectral...

Some 1-(4-chlorophenyl or benzenesulfonamide)-2,3- and/or 4-substituted-1H-pyrazol-5(4H)-one derivatives were synthesized and screened for their anti-inflammatory and analgesic activities, in addition to their ulcerogenic liability. They were found to be active as anti-inflammatory and analgesic agents. Compound 6b was found to be the most active as anti-inflammatory agent and compound 9b was f...

a new cyclic diarylheptanoid namely alnuheptanoid b (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-s-myricanol (2), myricanone 5-o--d-glucopyranoside (4), and (+)-s-myricanol 5-o--d-glucopyranoside (5) were isolated from the etoac fraction of alnus japonica steud (family: betulaceae) stem bark. their structures were established by different spectroscopic analyses, as ...

background most patients with trauma experience different levels of pain. due to side effects as well as economic burden of drugs used for pain relief after trauma commonly, it is important to use low-cost methods independently or combined with drugs to alleviate pain. objectives therefore, this study aimed to investigate the effects of topical sesame oil on pain severity and frequency of recei...