Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(-2)M and 10(-3)M, decreasing with increasing concentrations of streptokinase. The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca(++). C'2...

A series of new, covalent polyethylene glycol (PEG)-streptokinase adducts were synthesized and characterized. PEGs with average molecular weights of 2,000, 4,000, and 5,000 were activated with carbonyldiimidazole and coupled to the protein under standardized reaction conditions. Steady-state kinetic analysis demonstrated comparable Km values for the activation of plasminogen by streptokinase, P...

Neonatal tetanus (NT) is a leading cause of neonatal mortality in many parts of the world. Tetanus is a vaccine-preventable disease and is second only to measles worldwide as a cause of childhood mortality. In this study the various irnrnunoglobulin classes of anti-tetanus antibody in the sera of 105 Iranian women of childbearing age (13-45 years) were titrated by enzyme linked immunosorben...

Background: Infection is now the most common cause of morbidity in Systemic Lupus Erythematosus (SLE). There is lack of information regarding the specific antibody forma-tion in response to vaccines in young SLE patients. Objective: To determine the efficacy of anti-tetanus antibody response in young patients with SLE. Methods: Forty SLE pa-tients with mean age of 14.1 years (range: 7-21) and 6...

background and purpose: multiple sclerosis (ms) is believed to be an immune-mediated disorder that develops from an interaction of the individual's genetic and as yet unidentified environmental causes. the prevalence of auto-antibodies in multiple sclerosis patients and their clinical associations vary in various studies. the aim of this study was to determine serum auto antibodies in multiple ...

Background: The objective of this study is to establish importance of anti-FSH antibodies in IVF outcome. Materials and Methods: This research was designed based on evaluation of several articles from 2000 till 2012 about anti-FSH antibodies in IVF outcome. Results: Serum concentrations of anti-FSH IgG and IgA were linearly associated with poorer ovarian stimulation outcome. For example 1.0 AU ...

Background and Objectives: Vaccination is the major strategy to protect nurses against infection with hepatitis B virus. However, some nurses do not produce sufficient amount of anti-HBsAg antibody required for immunity against infection. Chronic occupational stress has been proposed as a risk factor to humoral immunity. Given that nursing staff is exposed to occupational stress risk, this stud...

Background and aim: An epidemiological association of lichen planus (LP) with hepatitis C virus (HCV) infection has been found only in certain parts of the world and in some countries no association has been noted. The present study was done to evaluate the association of LP with HCV in patients admitted to Sina hospital, Hamedan, Iran from 2002 to 2004.Materials and Methods: The presence of an...

OBJECTIVE To evaluate the influence of pretreatment streptokinase resistance titre and the concentration of IgG antibodies to streptokinase on the efficacy of thrombolytic drugs containing streptokinase in restoring coronary patency in acute myocardial infarction. DESIGN Comparative observational study. SETTING City general hospital. PATIENTS One hundred and twenty four previously unexpos...