Objective: The present study discusses the molecular docking of Hentriacontane for its Anti-tubercular and Anti-cancer activity. Methods: Two protein targets were selected their structures taken from RCSB Protein Data Bank in PDB format. Preparation proteins was done using Discovery Studio 2021 Client. structure drawn ChemDraw 20.0 saved Mol Molecular performed PyRx software. 3D 2D interactions...

Recent studies have indicated that 1, 4-dihydropyridine-3, 5-dicarboxamidederivativesshow significant anti-tubercular activity. In this research, new derivatives of 1, 4-dihydropyridine were designed and synthesized using Hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoylwere substituted at C-3 and C-5 positions of the DHP ring.In addition, 4 (5)-chloro-2-methyl-5 (...

Takayasu arteritis (TA) poses a diagnostic challenge as it may have myriad of clinical presentations. Dyspnea, an index presentation in TA, be secondary to the involvement aorta, myocardium, and/or pulmonary vessels, or can present manifestation infection with tuberculosis. Significant lymphadenopathy cannot attributed TA and serves point towards different diagnosis concomitant infection. Tuber...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...

Treatment of tuberculosis (TB) and the discovery of effective new anti-tubercular drugs are among the most urgent priorities in health organizations all over the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiaceta...

Coumarins are secondary plant metabolites widely distributed in higher plants, bacteria, fungi, and sponges. This great structural diversity of these natural compounds their synthesized derivatives enables wide range pharmacological activities, such as antioxidant; antibacterial; antifungal; anti-human immunodeficiency infection; anti-tubercular; anti-cancer which were very well reviewed previo...