We studied the activity of adenosine deaminase in 74 lymphocytic pleural effusions which were divided into four groups according to the aetiology: tuberculous (38 cases), neoplastic (17), lymphomatous (7) and miscellaneous (12). The mean enzyme value was significantly higher in the tuberculous cases (93.81 +/- 29.56 U/I) than for the other three groups and significantly higher in pleural effusi...

The aim of this study was to determine the usefulness of cancer antigen 125 (CA-125) serum levels in patients with tuberculosis (TB) with and without tuberculous serositis. A total of 64 TB patients with a mean age of 58.17 ± 19.05 years were enrolled in this observational case series study. All patients underwent blood sampling for the measurement of CA-125 serum levels before treatment. If th...

This case study revolves around a 38-year-old male patient who arrived at the Emergency department complaining of decreased levels consciousness, agitation, and disorientation. The follows his admittance to ICU, while team doctors worked on finding possible diagnosis for condition.
 It was later in course disease that it found from CSF(Cerebrospinal fluid) sample he suffering tuberculous m...

The diagnostic value of adenosine deaminase (ADA) activity was studied to evaluate its use in the differential diagnosis of tuberculous meningitis in the local setting. Cerebrospinal fluid (CSF) from 119 patients with meningitis and other conditions with central nervous system symptoms were collected and ADA activity determined by the colorimetric method of Guisti read at 628 nm. The CSF was al...

The monocyte/macrophage-derived cytokine, Tumor Necrosis Factor Alpha (TNF-α) plays a central role in effective granulomatous immunity to Mycobacterium tuberculosis infections in humans. The present study was conducted to document changes in the serum TNF-α level of patients after varying durations of anti-tuberculous therapy as compared to normal healthy controls. A comparative study was condu...

OBJECTIVES To compare the clinical and laboratory features of tuberculous meningitis with bacterial meningitis and to determine if protein glucose ratio in the cerebrospinal fluid can be predictive of the condition. METHODS It was a retrospective descriptive study at the Paediatric Ward of Aga Khan University Hospital, Karachi, for which records of 46 patients with tuberculous meningitis and ...

We report a 38-year-old Chinese woman with lupus nephritis on peritoneal dialysis and long-term maintenance steroid therapy. This patient developed paradoxical deterioration during anti-tubercular therapy for tuberculous lymphadenitis. The deterioration resolved spontaneously without change to pharmacotherapy. Paradoxical deterioration that may spontaneously resolve is a potential complication ...

•Routine 2-week liver tests were evaluated in a 1247 patient cohort treated for TB. •Anti-tuberculous therapy (ATT) led to drug-induced injury (DILI) 8.3%. •Risk of late TB-DILI increased 2.2-fold every 30 U/L rise pre-treatment ALT. 2.1-fold gradient ALT change. Objective Tuberculosis Drug Induced Liver Injury (TB-DILI) is common and potentially severe complication associated with anti-tubercu...

purpose : to report a patient with orbital tuberculosis (tb) without any history of systemic involvement case report : a 41-year-old afghani man who presented with progressive painless swelling in lateral side of the left upper eyelid and diplopia. he did not have history of fever or pulmonary disease. histopathology revealed a granulomatous inflammation with caseation necrosis. microbiological...