Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...

despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. one major limitation of cytotoxic drugs and radiation in the treatment of cancer patients is their inability to discriminate between malignant and normal tissues. this in tu...

background: preeclampsia (pe) is a pregnancy specific syndrome that is associated with high maternal and fetal morbidity and mortality. glucose regulated protein78 (grp78) is an endoplasmic reticulum (er) protein which is expressed on the cell surfaces of trophoblast cells under stress or hypoxic condition. grp78 has a role in aggressive behavior of invasive cells and may play a role in normal ...

Background: Streptokinase, which is injected intravenously with a standard dose of 1.5 MIU, is the most widely used thrombolytic agent around the world. What is so important about this bioproduct is the level of antistreptokinase (anti-sk) antibody in the population, which is directly correlated to the incidence of streptococcal infections in that population. Objective: Since Iran is an endemic...

The major challenge of nanocarrier-based anti-cancer vaccination approaches is the targeted delivery antigens and immunostimulatory agents to cells interest, such as specific subtypes dendritic (DCs), in order induce robust antigen-specific anti-tumor responses. An undirected cell body distribution nanocarriers can lead an unwanted other immune types like macrophages reducing vaccine efficacy. ...

Background and Aims: A subgroup of group O individuals called ‘dangerous universal donors’ have immune (IgG) anti A and anti B antibodies which are active at 37˚C and capable of reacting with the red cells and causing lysis. The aim of this study was to find the prevalence of dangerous O group among the voluntary donor population and to assess the relation between the degree of haemolysis and t...

background and objective: presence of hepatitis b core antibody (anti-hbc) in the absence of hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs) is defined, as isolated anti-hbc. little is known about the clinical significance of the isolated anti-hbc in hepatitis b virus (hbv) infections. the aim of this study was to assess the significance of anti-hbc as the only m...

G12 monoclonal antibody (mAb), one of a library of constructed mAb directed against human sperm proteins, was found by immunoperoxidase staining to label the post-acrosomal and neck regions of fixed human cauda epididymal and ejaculated spermatozoa. Epithelium and fluid of caput epididymis were strongly labelled while there was no staining on testis and efferent ducts. Western lot analysis reve...