Seven new 2-(3-(4-aryl)-1-phenyl-1H-pyrazol-4-yl) chroman-4-ones (4a-4g) have been synthesized by cyclization of 2-hydroxychalcone analogues of pyrazole 3a-3g using conc. HCl in acetic acid. The structures of the compounds 4a-4g were established by the combined use of (1)HNMR, IR and mass spectra. All the seven compounds were tested in vitro for their antibacterial activity against two Gram pos...

phytochemicals are good sources of natural antioxidants and have beneficial effects on human health. many of phenolic phytochemicals have shown antimicrobial and antifungal activity. anise hyssop ( agastache foeniculum [pursh] kuntze ) is a perennial aromatic plant of the lamiaceae family with antimicrobial and antifungal properties and useful for gastrointestinal problems. in this investigatio...

vilsmeier several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. the diversity of these quinolinyl ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good an...

The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixtu...

Novel oligomer metal complexes (2a-f) of the ligand 2,5-bis((4-bromophenyl)carbamoyl) terephthalic acid (1) were prepared using transition metal salts and characterized by various spectroscopic techniques. The geometry of oligomer metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. Polymeric properties have also been carried out. Ligand was synthesi...

BACKGROUND Mindium laevigatum (Vent.) Rech. F. plant grows in central part of Iran. And used by local people as medical plant. OBJECTIVES The purpose of this study was to investigate the in vitro antibacterial, antifungal and antioxidant activities of the methanolic extracts of aerial and flower parts of plant. MATERIALS AND METHODS The leaves and stem and flower of bark from M. laevigatum ...

INTRODUCTION Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro. METHODS The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recomme...