Three small-subunit ribosomal proteins shown to influence translational accuracy in Saccharomyces cerevisiae are conserved in structure and function with their procaryotic counterparts. One of these, encoded by RPS28A and RPS28B (RPS28), is comparable to bacterial S12. The others, encoded by sup44 (RPS4) or, sup46 and YS11A (RPS13), are homologues of procaryotic S5 and S4, respectively. In Esch...

Introduction: Antibiotic therapy is usually given to protect from infection against various organisms, however, routine use of empirical treatment has resulted in widespread antibiotic resistance and development of antibiotic resistant genes. Objective: To identify the bacterial pathogens isolated from various clinical specimens and to determine their antibiotic sensitivity and resistance patte...

BACKGROUND AND OBJECTIVES Cystic fibrosis patients suffer from chronic lung infections that require long-term antibiotic therapy. Pseudomonas readily evolve resistance, rendering antibiotics ineffective. In vitro experiments suggest that resistant bacteria may be treated by exploiting their collateral sensitivity to other antibiotics. Here, we investigate correlations of sensitivity and resista...