Chlamydia species are susceptible in vitro to certain antibiotics, and various tetracyclines, macrolides, and fluoroquinolones are used for the treatment of Chlamydia trachomatis infections. Less is known about the in vitro susceptibility and chemical response to infection with Chlamydia pneumoniae. Results of in vitro studies from the literature and from my laboratory employing a tissue cultur...

The in vitro activity of various antibiotics against Pseudomonas pseudomallei was studied. The tetracyclines were the most active, followed by gentamicin, kanamycin, novobiocin, chloramphenicol, rifampin, cycloserine, erythromycin, and ampicillin.

The susceptibility of 128 clinical isolates of Pseudomonas aeruginosa against amikacin, kanamycin, gentamycin, minocycline, colistin, chloramphenicol, claforan , piperacillin and carbenicillin were tested. Piperacillin, carbenicillin, amikacin and claforan are effective against at least 54% of strains tested. The susceptibilities of microorganisms to antibiotics were evaluated in different poin...

We evaluated the in vitro susceptibility of Legionella pneumophila ATCC 33152 (serogroup I) to 13 antibiotics alone and in combination with rifampin (0.1 mg/liter) by three methods. Extracellular susceptibility was determined by MIC determinations and time kill curves in buffered yeast extract broth, while intracellular susceptibility was determined by peripheral human monocytes in RPMI 1640 cu...

Bacterial growth environment strongly influences the efficacy of antibiotic treatment, with slow growth often being associated with decreased susceptibility. Yet in many cases, the connection between antibiotic susceptibility and pathogen physiology remains unclear. We show that for ribosome-targeting antibiotics acting on Escherichia coli, a complex interplay exists between physiology and anti...

..................................................................................................................................... 3 Abbreviations ............................................................................................................................. 4 Background ...............................................................................................................