Ten years after the first clinical application of Rituximab, an anti-CD20 recombinant monoclonal antibody, immunotherapy has become common practice in oncology wards. Thanks to the great diversity of the immune system and the powerful methodology of genetic engineering, the pharmacologic potential of antibody-based therapy is far from exhaustion. The recent application of Trastuzumab, an antibo...

A combination of phage display antibody technology and a subtraction method provides a powerful tool for the isolation of novel biomarkers. However, the dilemma that high stringency screening often reduces the diversity in the subtracted phage antibody repertoires and that it is difficult to isolate phage antibody against rare epitopes remain. Therefore, we carefully monitored the occupancy of ...

Green space is important for the maintenance of the ecological dimension of a sustainable urban landscape. Therefore, in order to figure out the relationship between the greening of urban parks and bird diversity, we used 5 avian ecological diversity indexes, such as Species richness, Abundance, ShannonWeiner diversity index, Evenness, and Margalef’s richness indices, to evaluate the functional...

We study the consequences of introducing individual nonconformity in social interactions, based on Axelrod’s model for the dissemination of culture. A constraint on the number of situations in which interaction may take place is introduced in order to lift the unavoidable homogeneity present in the final configurations arising in Axelrod’s related models. The inclusion of this constraint leads ...

A high degree of topical diversity is often considered to be an important characteristic of interesting text documents. A recent proposal for measuring topical diversity identifies three elements for assessing diversity: words, topics, and documents as collections of words. Topic models play a central role in this approach. Using standard topic models for measuring diversity of documents is sub...

This document explains diversity related methods in vegan. The methods are briefly described, and the equations used them are given often in more detail than in their help pages. The methods discussed include common diversity indices and rarefaction, families of diversity indices, species abundance models, species accumulation models and beta diversity, extrapolated richness and probability of ...

By analyzing the human antibody repertoire in terms of structure, amino acid sequence diversity and germline usage, we found that seven V(H) and seven V(L) (four Vkappa and three Vlambda) germline families cover more than 95 % of the human antibody diversity used. A consensus sequence was derived for each family and optimized for expression in Escherichia coli. In order to make all six compleme...

When an animal is infected, either naturally or by experimental injection, with a bacterium, virus, or other foreign body, the animal recognises this as an invader and acts in such a way as to remove or destroy it. There are millions of different chemical structures that the animal has never seen and yet which it is able to recognise in a specific manner. How is this achieved? Scientists have b...

Habitat distribution and seasonal occurrence of carabid beetles were determined using pitfall traps in 1999 and 2000 in the temperate forest zone of the Dongling Mountain, North China. Eight sites differing in vegetation and moisture were selected so as to represent four habitat types. Carabid assemblages of the six forested habitats (lowland, upland and coppice) were more similar to each other...