Known polyene amide, clathrynamide A, and three novel related metabolites, debromoclathrynamide A, (4E,6E)-debromoclathrynamide A and (6E)-clathrynamide A, were isolated from an Okinawan marine sponge, Psammoclemma sp. The absolute stereochemistry of clathrynamide A was determined to be 3R,12R by the modified Mosher method. The structures of the three new compounds were elucidated by spectrosco...

Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to the rising number of immunocompromised patients. However, the available antifungal therapeutic arsenal is limited, and the development of new drugs has been slow. Therefore, the search for alternative drugs with low resistance rates and fewer side effects remains a major challenge. Plants produce a varie...

Tragia is well known in the botanical world a stinging plants. Apart from this, genus also occupies an important constituent of alternative systems medicine as ethnobotany. Among various species Tragia, most studied and experimented T. involucrata. This used for several ethnobotanical uses such cancer, diarrhea, constipation, scorpion bite, rheumatism, whooping cough diabetes. this ayurvedic si...

Lactobacillus strains with the potential of protecting fresh dairy products from spoilage were studied. Metabolism and antifungal activity different L. plantarum, brevis, sakei strains, isolated Sardinian meat products, assessed. The metabolite fingerprint each strain was obtained by GC-MS data submitted to multivariate statistical analysis. discriminant analysis correctly classified samples sp...

Abstract The antifungal activity of Trichoderma hamatum K01 to control Colletotrichum gloeosporioides C01 was recorded. Pathogenicity C. on citrus leaves confirmed by the Koch postulate. T. inhibited colony growth and conidia production 70.55 79.07%, respectively. Crude extracts from expressed an against C01. crude TK01-MeOH showed most potent inhibitory effect at ED 50 values 273 355 ppm, Nano...

Pseudomonas chlororaphis PCL1391 produces the secondary metabolite phenazine-1-carboxamide (PCN), which is an antifungal metabolite required for biocontrol activity of the strain. Identification of conditions involved in PCN production showed that some carbon sources and all amino acids tested promote PCN levels. Decreasing the pH from 7 to 6 or decreasing the growth temperature from 21 to 16 d...