An effective public health strategy against the development of antimicrobial drug resistance needs to be informed by legal as well as scientific analysis. This article describes some legal issues arising from current efforts against antimicrobial resistance and underscores the interdependence between law and public health in these efforts.

2010 had distinct random amplifi ed patterns that differed from those generated from isolates A–G (Figure). A previous study in Taiwan showed that the incidence (no. cases/100,000 inpatients and outpatients) of all pulmonary disease caused by NTM increased signifi cantly from 2.7 (1.26) in 2000 to 10.2 (7.94) in 2008 (6). The most common organism in localized pulmonary infection and disseminate...

Resistance of Streptococcus pneumoniae to antimicrobial drugs is increasing. To investigate the relationship between antimicrobial use and susceptibility of S. pneumoniae isolates at 24 U.S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-la...

Innovative regulatory and legislative measures to stimulate and facilitate the development of new antimicrobial drugs are needed. We discuss research approaches that can aid regulatory decision making on the treatment of resistant infections and minimization of resistance selection. We also outline current and future measures that regulatory agencies may employ to help control resistance and pr...

We need new treatment options to control bacterial infections. Bacteria use several strategies resist drug treatment, including modification of the target, and adaptation a different lifestyle, such as intracellular niches within host cells. Drugs that act on diverse targets are less likely induce resistance in bacteria, than current antibiotics acting single molecular target. Antimicrobial pep...

In the 20th century, antibiotics were regarded as a "wonder drug," but due to overuse, bacteria have become resistant them, giving rise highly superbugs that can live in presence of drugs intended stop them from multiplying. There are several mechanisms behind antimicrobial resistance. Antibiotic resistance typically be acquired by drug-susceptible genetic mutation or gene transfer, with horizo...

Antimicrobial resistance profiles were determined for Neisseria gonorrhoeae strains isolated in Canada during 2010-2014. The proportion of isolates with decreased susceptibility to cephalosporins declined significantly between 2011 and 2014, whereas azithromycin resistance increased significantly during that period. Continued surveillance of antimicrobial drug susceptibilities is imperative to ...

Population mobility is a main factor in globalization of public health threats and risks, specifically distribution of antimicrobial drug-resistant organisms. Drug resistance is a major risk in healthcare settings and is emerging as a problem in community-acquired infections. Traditional health policy approaches have focused on diseases of global public health significance such as tuberculosis,...

To determine antimicrobial drug resistance mechanisms of Shigella spp., we analyzed 344 isolates collected in Switzerland during 2004-2014. Overall, 78.5% of isolates were multidrug resistant; 10.5% were ciprofloxacin resistant; and 2% harbored mph(A), a plasmid-mediated gene that confers reduced susceptibility to azithromycin, a last-resort antimicrobial agent for shigellosis.

We investigated whether outpatient antimicrobial drug prescribing is associated with Neisseria gonorrhoeae antimicrobial drug susceptibility in the United States. Using susceptibility data from the Gonococcal Isolate Surveillance Project during 2005-2013 and QuintilesIMS data on outpatient cephalosporin, macrolide, and fluoroquinolone prescribing, we constructed multivariable linear mixed model...