In 2012, on behalf of the Australasian Society for Infectious Diseases (ASID), we reported in the Journal on the infectious diseases challenges for Australia in the coming decade.1 We identified antimicrobial resistance (AMR) as a public health crisis requiring global professional and political action, and reflected on how the spread of infectious diseases and AMR is affected by interconnected ...

Bacterial infections cause 300 million cases of severe illness each year worldwide. Rapidly accelerating drug resistance further exacerbates this threat to human health. While dispersed (planktonic) bacteria represent a therapeutic challenge, bacterial biofilms present major hurdles for both diagnosis and treatment. Nanoparticles have emerged recently as tools for fighting drug-resistant plankt...

For more than a century, bacteriophage (or phage) research has enabled some of the most important discoveries in biological sciences and has equipped scientists with many of the molecular biology tools that have advanced our understanding of replication, maintenance, and expression of genetic material. Phages have also been recognized and exploited as natural antimicrobial agents and nanovector...

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

orofacial granulomatosis(ofg) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissues swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. ofg may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. the...

The design and use of new potent specific antimicrobial systems are crucial importance in the medical field. This will help relieve, fight, eradicate infections thus improve human health. metals various forms as therapeutics has been known since ancient times. In this sense, polymeric hydrogel matrices multifunctional materials combination with metal can be a great alternative to conventional t...