Potential difference across the cell membrane and intracellular activity of the potassium ion in rat liver cells were measured simultaneously using double-barreled potassium ion-selective microelectrodes. Both potential difference across the membrane and K+ activity in liver cells were depressed after treatment with the antineoplastic agents mitomycin C and 5-Flourouracil Dry Syrup, suggesting ...

With the aim of overcoming well-known limitations platinum-based antineoplastic drugs, recent efforts have focused on development new anticancer agents containing metals other than platinum. Among these agents, organopalladium compounds received significant attention due to their generally high stability under physiological conditions. A number shown promising in vitro and vivo antiproliferativ...

Malignant tumors are potential killers of human life, seriously endangering people’s physical health. As far as the treatment malignant is concerned, there exist many therapeutic methods such surgery, radiotherapy, chemotherapy, among which chemotherapy an important means antitumor therapy. Chemotherapy antineoplastic agents can be divided into alkylating agents, metalloplatinum, plant drugs, a...

This article documents that hydroxyurea (HUR) is excreted into human breast milk, and it reviews the literature describing similar evaluations for other antineoplastic agents.

Many commonly used drugs, with each causing changes that may be potentially lethal, can adversely affect the function of the heart. In addition some drugs have synergistic effects that can also damage cardiovascular tissues. The drug-related cardiotoxic effects of antineoplastic agents, psychotropic medications, heavy metals, substances of abuse, promotility agents, antihistamines, antimicrobia...