To date, none of the available antipsychotic drugs are curative, all have significant side-effect potential, and a receptor-binding profile predictive of superior therapeutic ability has not been determined. It has become increasingly clear that schizophrenia does not result from the dysfunction of a single neurotransmitter system, but rather from an imbalance between several interacting system...

Condensation of o-phenylenediamine with isatine in refluxing glacial acetic acid gives indolo[2,3-b] quinoxaline. This moiety further condensed with n’-(n-Halo aloxy)-3,4-dihydro carbostyril in refluxing acetonitrile using NaI,K2CO3 and TBAB as catalyst gave us desire product. Series of all six analogs are taken for their antibacterial and antipsychotic activity. The entire tested compound show...

drug induced dystonic reactions are among common presentations of patients in emergency departments, and typically occur with antidopaminergic agents as their extra-pyramidal side effects. dystonic reactions usually occur within the first few hours or days after commencing a drug or dose increase. unlike other extra-pyramidal side effects, a patient may experience acute dystonic reactions (adrs...

Rat genomic clones were used to quantitate preprotachykinin mRNAs in the rat basal ganglia, while the tachykinin peptide products substance P and substance K were measured by radioimmunoassay. Administration of the dopamine antagonist (antipsychotic) drug haloperidol significantly decreased substance P, substance K, and both alpha (substance P encoding) and beta (substance P/substance K encodin...

OBJECTIVE This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression. METHODS The study enrolled 64 patients meeting the Diagnostic an...

BACKGROUND People with schizophrenia are often found to have smaller brains and larger brain ventricles than normal, but the role of antipsychotic medication remains unclear. METHOD We conducted a systematic review of magnetic resonance imaging (MRI) studies. We included longitudinal studies of brain changes in patients taking antipsychotic drugs and we examined studies of antipsychotic-naive...

Pharmacological intervention is the commonest mode of managing patients with schizophrenia. Both clinicians and patients are concerned that antipsyohotic drugs are costly and contribute to poor drug compliance in India. This study compared the equivalent doses of antipsychotic drugs and their costs across brands. Results show that antipsychotic drugs are affordable and are comparable to drug tr...

The expected therapeutic effect of estrogen as an adjunct treatment to antipsychotics in women suffering from schizophrenia for relapse prevention was to be tested under real-life conditions. A multicenter, randomized, placebo-controlled, double-blind, cross-over study based on an A-B-A-B (and/or B-A-B-A) design was applied. Forty-six hypoestrogenic women with schizophrenia hospitalized for the...

BACKGROUND Antipsychotic therapy is widely used to treat behavioral problems in older adults with dementia. Cohort studies evaluating the safety of antipsychotic therapy generally focus on a single adverse event. We compared the rate of developing any serious event, a composite outcome defined as an event serious enough to lead to an acute care hospital admission or death within 30 days of init...

Antipsychotic drugs temper psychotic symptoms by interacting with dopamine D2 receptors to reduce neurotransmission. Currently, the standard of care involves antipsychotic treatment protocols that achieve steady-state levels medication. Maintaining patients on continuous is thought be necessary keep them stabilised. However, exposure increases risk adverse effects over time. These include metab...