Introduction BioSense is a national human health surveillance system for disease detection, monitoring, and situation awareness through near realtime access to existing electronic healthcare encounter information, including information from hospital emergency departments (EDs). MCM include antibiotics, antivirals, antidotes, antitoxins, vaccinations, nuclide-binding agents, and other medication...

on the modern system, the old nomenclature is also given. The chapters on filtrable viruses, immunity, bacterial virulence, toxin, antitoxins and agglutinins are particularly good for the concise and comprehensive way in which these subjects have been dealt with. The inclusion of the more important pathogenic protozoa in a small chapter will be appreciated by the busy practitioner though it is ...

A survey of titres of diphtheria and tetanus antitoxins and of antibodies to polioviruses in the sera of 291 schoolchildren aged 15, 11, and 7 years showed that high immunisation rates can evoke protective concentrations of tetanus antitoxin in 98% of children and protective levels of the antibodies to diphtheria and all three types of poliomyelitis in 85% of children. Reinforcing immunisation ...

In January and February 1992, an assessment was conducted of the safety and immunogenicity of two doses of a new oral cholera vaccine prepared from the recombinant B subunit of the toxin and from killed whole cells (rBS/WC) in 1,165 individuals between the ages of 12 months and 64 years in Barranquilla, Colombia. This was a randomized, double-blind placebo-controlled study. Participants receive...

Serotherapy for the treatment of diphtheria represented a major therapeutic innovation at the end of the nineteenth century. The manner in which large-scale production of this medicament was undertaken and the regulations that governed its production and distribution were important elements of public health policy in France as in other European countries. This paper describes the dominance of t...

The Reputed Conflict between the Laboratories and DR. G. MuRAY MCKiNLEY. Beducing Moisture Clinical Medicine: THE LATE DR. C. F. HOOVER ...... 491 Evaporation from Petri Dish Cultures: DR. E. E. HUBERT and T. H. HARIs .508 Obituary: The Scientific Work of Etienne S. Bieler: PROSpecial Articles: FESSOR L. V. KING. Henry Chapman Mercer: The Displacement of Toxin from Neutralized ALBERT MOYER .......

Type A botulinum toxin was studied for its ability to inhibit the action of acetyl-cholinesterase. The chromogenic substrate, indophenyl acetate, was used for assay of enzyme activity. Inhibition of enzyme function was detected through use of both 6.6 x 10(-6) mg (20 ld(50)) and 6.6 x 10(-10) mg (2 x 10(-3)ld(50)) of type A botulinal toxin. Control assays were performed by use of both homologou...

ence has reached its fifth edition. It contains a vast amount of information on the pharmacopoeias of all nations, it gives a synopsis not only of the B. P. and its addendum, but also synopses of the pharmacopoeias of all continental countries (including German and Austrian), and also the Japanese one. After these come a long list of useful formulae, notes on hypodermic injections, antitoxins, ...