Abstract. A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons 4-sulfonamide phenylhydrazine hydrochloride with better yields. The pyrazole screened for anti-TB, anti-bacterial, anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a 3b showed selective potent anti-tubercular nature (MIC 6.25µg/mL). Further, antimicrobial studies c...

Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regi...

Tuberculosis infection is of global public health significance, with millions of incident cases each year. Many cases, particularly in low-prevalence settings, result from the reactivation of latent tuberculosis infection (LTBI); potentially acquired years prior to active disease. Up to one-third of the world's population has been infected with LTBI, and so may be at risk for future active TB d...

Success in tuberculosis control depends on the implementation of steps that reduce social inequities, allowing the diagnosis and effective treatment of the disease. Little is known about the conditions affecting antituberculosis treatment non-adherence in areas of great social and economic heterogeneity, such as the municipality of Rio de Janeiro. This study aimed to describe and identify the s...