The biological activities of natural abietane acids and their derivatives have been reviewed from 1967 to 1992. Antimicrobial, antiulcer, and cardiovascular activities are the most representative for this class of diterpenoids, while others like allergenic, antiallergic, filmogenic, surfactant, antifeedant, etc. activities, which determine several uses of abietane acids, have also been reported.

The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani, the causative agent of visceral leishmaniasis. Promastigotes cultured at acidic pH and amastigotes within infected macrophages are reduced 90% or more with 150 microM omeprazole. Antiparasitic action of the drug is due to its inhibition of the P-type K(+),H(+...

BACKGROUND: Bacterial gastroenteritis is a disease in the tropics form of inflammation stomach and intestines due to several bacteria, such as Salmonella, Campylobacter, Shigella, Escherichia coli, Vibrio, Yersinia, Listeria with symptoms diarrhea without or vomiting frequent fever. Gastroenteritis global highest prevalence agricultural community, especially farmers fishermen. AIM: This researc...

malvastrum tricuspidatum is recommended in ayurveda and folklore medicine for the management of gastric ulcers. therefore, the purpose of the study was to investigate the antiulcer effect of whole plant extract of malvastrum tricuspidatum (mte) on ethanol (etoh)-induced, aspirin (asp)-induced, cold-restraint-stress (cru) and pylorus--ligation(pl)-induced gastric ulcer models in rats. aqueous ex...

Malvastrum tricuspidatum is recommended in Ayurveda and Folklore Medicine for the management of gastric ulcers. Therefore, the purpose of the study was to investigate the antiulcer effect of whole plant extract of Malvastrum tricuspidatum (MTE) on ethanol (EtOH)-induced, aspirin (ASP)-induced, cold-restraint-stress (CRU) and pylorus--ligation(PL)-induced gastric ulcer models in rats. Aqueo...

An imbalance in the aggressive factors and protective gastrointestinal tract leads to peptic ulcers. Modern medicinal prescriptions for ulcers involve use of allopathic drugs. However, several disadvantages, such as side effects, discordancy, altered physiological aspects, have led quest alternative safer medications. The herbs treat has been practiced decades Ayurveda. A combination herbs, kno...