II ED CELL APLASIA is an anemia characterized by a marked reduction in the number of marrow erythroblasts.1’2 Although cases have been reported in which the blood leukocyte or thrombocyte count was also reduced, the marrow usually has a normal cellularity, normal granulopoiesis and normal megakaryocytopoiesis.1’2 \Vhile red cell aplasia is a somewhat rare disease, only 150 cases having been rep...

In the female, Müllerian ducts will develop to form the uterine tubes, uterus, cervix, and the upper one-third of the vagina; in the male, they are lost. This abnormal development can lead to uterine malformations resulting from aplasia of a part of Müllerian duct. Morphological abnormalities can vary from insufficient fission of tissues causing bicornuate uterus, double uterus or preserved ute...

Unilateral pulmonary artery aplasia is a rare anomaly. Case reports of this condition in pregnant patients are even more uncommon and the best approach to management of such patients is still unclear. We report a patient who presented with a history of dyspnea, chest pain, and hemoptysis. Imaging established the diagnosis in a newly pregnant female. Management of the pulmonary artery aplasia pa...

In the female, Müllerian ducts will develop to form the uterine tubes, uterus, cervix, and the upper one-third of the vagina; in the male, they are lost. This abnormal development can lead to uterine malformations resulting from aplasia of a part of Müllerian duct. Morphological abnormalities can vary from insufficient fission of tissues causing bicornuate uterus, double uterus or preserved ute...

Membranous, bullous, or cystic aplasia cutis congenita is a clinical subtype of aplasia cutis, covered with a membranous or glistening surface. A male newborn presented at birth with two flat lesions on the left parietal scalp, surrounded by a rim of terminal hairs. Physical examination revealed two translucent papules. On dermoscopy, they showed a reddish background, thin, lineal vessels and, ...

Thrombocytopenia-absent radius (TAR) syndrome is an autosomal-recessive disorder characterized by a thrombocytopenia and a bilateral radial aplasia with normal thumbs. Only TAR syndrome, out of diseases which may present with radial aplasia, typically has normal thumbs. The prenatal diagnosis is rarely made. We report two observations of TAR syndrome diagnosed in utero in the sibling. The malpo...

1. Charles RJ, Sabo KM, Kidd PG, Abkowitz JL. The pathophysiology of pure red cell aplasia: implications for therapy. Blood 1996; 87:4831-8. 2. Weiss RB, Freiman J, Kweder SL, Diehl LF, Byrd JC. Hemolytic anemia after fludarabine therapy for chronic lymphocytic leukemia. J Clin Oncol 1998; 16:18859. 3. Leporrier M, Reman O, Troussard X. Pure red-cell aplasia with fludarabine for chronic lymphoc...

Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, hypogammaglobulinaemia, pancytopaenia, collagen diseases, and, most commonly, myasthenia gravis. The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of ...