The accuracy of a diagnostic test with continuous-scale results is of high importance in clinical medicine. It is often summarised by the area under the ROC curve (AUC). In this article, we discuss and compare nine non-parametric confidence intervals of the AUC for a continuous-scale diagnostic test. Simulation studies are conducted to evaluate the relative performance of the confidence interva...

The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [...

BACKGROUND Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study was performed to examine the placebo response in SIT trials that employed a ba...

PURPOSE Investigate the role of metabolites in bioequivalence (BE) assessment. METHODS. Sets of ordinary differential equations are used to generate concentration - time data for both parent drug (P) and metabolite (M). The calculations include 24 subjects, two different formulations (Test, Reference), and a range of Test/Reference ratios for the fraction of dose absorbed and the rate of absorp...

Omland and colleagues’ paper examining the outcome of IVF in a ‘natural cycle’ model to study aetiological differences between endometriosis and other infertility groups interested us (Omland et al., 2001). Their findings differ from ours and we have tried to understand these differences. It is important to distinguish between this study, which used HCG as a surrogate for the endogenous LH surg...

I. Background Concern about the environmental costs of economic development is now both widespread and intense. At one extreme, environmental deterioration, as through air and water pollution and deforestation, is seen as an unavoidable cost of industrialization, urbanization, and the growth of consumption (and the change in its composition) that are at the heart of “development” in the common ...

PURPOSE This study investigated the pharmacokinetics of tinidazole in subjects of five different Chinese nationalities (Han, Mongolian, Korean, Hui, and Uighur). METHODS Fifty healthy subjects (five male and five female of each nationality) were recruited for the study, and each received 1 g tinidazole. A total of 14 blood samples were collected over a 72-hour period after administration. R...

A fully automated and computationally efficient Pearson's correlation change classification (APC3) approach is proposed and shown to have overall comparable performance with both an average accuracy and an average AUC of 0.89 ± 0.08 but is 3.9 to 7 times faster, easier to use and have low outlier susceptibility in contrast to other dimensional reduction and classification combinations using onl...

We propose a method that uses off-the-shelf binary classifiers and combines them in real-time to achieve quality, time, and cost characteristics that satisfy user-provided constraints; moreover, it shares intermediate computation (e.g., features, classifiers, kernels) between classes to reduce time and cost. An important distinction between this approach and others is that the primary focus of ...

BACKGROUND Previous studies have revealed conflicting results for the Breastfeeding Assessment Score (BAS) in predicting early breastfeeding cessation. Our objective was to externally validate the BAS and provide summary accuracy estimates for this clinical prediction model. METHODS We used the original data from a prospective cohort study. Additional studies were identified by searching elec...