A new analysis strategy was used to classify the carcinogenicity of aromatic amines. The physical-chemical parameters are closely related to the carcinogenicity of compounds. Quantitative structure activity relationship (QSAR) is a method of predicting the carcinogenicity of aromatic amine, which can reveal the relationship between carcinogenicity and physical-chemical parameters. This study ac...

a phosgene-free synthesis of symmetrical n,n'-disubstituted urea by the reaction of aromatic and aliphatic primary amines and urea promoted by  microwave irradiation in the presence of a suitable energy-transfer solvent such as n-n-dimethylacetamide is described.

an one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of bi(no3)3. 5h2o. short reaction times, high yields, a clean process, simple methodology, easy work-up and green ‎conditions are advantages of this protocol.‎

The O(2)-sensitive reduction of high-molecular-weight aromatic azo and nitro dyes by intestinal bacteria appears to be mediated by low-molecular-weight electron carriers with E(o)' = -200 to -350 mV. This process may allow the design of polymeric azo prodrugs for specific release of certain aromatic amines in the colon.

Polycyclic aromatic hydrocarbons and aromatic amines exercise a highly specific influence on the crystallization of cholesterol. The strength of these non-covalent, presumably epitaxial interactions correlates with the carcinogenic activity of these substances. The presented results are in support of the assumption that a specific process of adsorption and crystallization with cholesterol of th...

A one pot domino protocol for an efficient synthesis of 7-arylbenzo[c]acridine-5,6-diones, with a novel nucleus, has been developed by reacting 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and aromatic amines using environmentally benevolent p-toluene sulphonic acid as a catalyst. An exciting feature of this communication is the reaction mechanism that depends on the reaction solvent.

Diet has been associated with varying cancer rates in human populations for many years, yet the causes of the observed variation in cancer patterns have not been adequately explained (Wynder et al., 1977). Along with the effect of diet on human cancer incidence is the strong evidence that mutations are the initiating events in the cancer process (Vogelstein et al., 1992). Foods, when heated, ar...

a convenient, one-pot method for the synthesis of diazonium salt has been developed by the sequential diazotization of aromatic amines with nano2, polymer- supported periodic acid (ppia) and 2-naphthole under solvent-free conditions at room temperature. by using this method, several types of aromatic amine, containing electron-withdrawing and electron-donating groups, were rapidly converted to ...

A ruthenium phthalocyanine catalyzes the cyclopropanation of olefins (15 substr.) and single carbene insertion into N–H bonds aromatic, heteroaromatic aliphatic amines (20 with high selectivity under practical reaction conditions.