Objectives: The objective of this work is to present the software tool ANTONIA, which has been developed to facilitate a quanti tative analysis of perfusion-weighted MRI (PWI) datasets in general as well as the subsequent multi-parametric analysis of additional datasets for the specific purpose of acute ischemic stroke patient dataset evaluation. Methods: Three different methods for the analysi...

The pharmacokinetic model has been widely used in tissue perfusion analysis, such as bone marrow perfusion. In the modeling process, the arterial input function is important to guarantee the reliability of the fitting result. However, the arterial input function is variable and hard to control, which makes it difficult to compare results across different studies. The purpose of this study was t...

We previously developed a noninvasive technique for the quantification of fluorodeoxyglucose (FDG) positron emission tomography (PET) images using an imagederived input function obtained from a manually drawn carotid artery region. Here, we investigate the use of independent component analysis (ICA) for more objective identification of the carotid artery and surrounding tissue regions. Using FD...

Introduction: Dispersion of labelled blood water is a recognised issue in the quantification of cerebral blood flow (CBF) using arterial spin labelling (ASL). The ASL signal measured in the tissue is the result of labelled blood water, described by an arterial input function (AIF), undergoing exchange with the extra-vascular space [1]. Dispersion occurs during the transit of the blood along the...

The authors developed and tested a method for the noninvasive quantification of the cerebral metabolic rate for glucose (CMRglc) using positron emission tomography (PET), 18F-fluoro-2-deoxyglucose, the Patlak method, and an image-derived input function. Dynamic PET data acquired 12 to 48 seconds after rapid tracer injection were summed to identify carotid artery regions of interest (ROIs). The ...