objective: despite development of new contraceptive methods, sterilization remained the most widely used method. our objective was to determine the factors contributing to decision making for tubal ligation in females. materials and methods: a cross sectional study was conducted in jinnah post graduate medical centre (jpmc) between march - november 2008. about 505 females using contraceptive me...

5-Methoxytryptophan (5-MTP), a 5-methoxyindole metabolite of tryptophan metabolism, was recently shown to suppress inflammatory mediator-induced cancer cell proliferation and migration. However, the role of 5-MTP in vascular disease is unknown. In this study, we investigated whether 5-MTP protects against vascular remodeling following arterial injury. Measurements of serum 5-MTP levels in healt...

Background If only proximal embolization or ligation is performed for an internal iliac artery aneurysm (IIAA), transcatheter arterial embolization is sometimes difficult due to complex collateral circulation. A new method of direct percutaneous n-butyl-2-cyanoacrylate (NBCA) sac embolization (b-DNSE) under balloon arterial occlusion for re-intervention of an IIAA after proximal ligation is pre...

OBJECTIVE Impaired regeneration of endothelial cells (EC) and overactivity of vascular smooth muscle cells (VSMC) are hallmarks of the arterial lesions associated with aging. The occurrence of 2 opposing cellular processes in the same arterial milieu makes pharmaceutical treatment difficult to develop. We previously reported that endothelial expression of a Notch ligand (Jagged1) was reduced in...

Abstract We report a case of hydrocephalus with Dandy–Walker malformation in 2-month-old girl child recently recovered from COVID-19. The was detected to have acyanotic heart disease left-to-right shunt and severe pulmonary arterial hypertension during the preoperative evaluation process for ventriculoperitoneal (VP) placement. share our experience perioperative management artery banding (PAB) ...

Yang, H. T., and Y. Feng. bFGF increases collateral blood flow in aged rats with femoral artery ligation. Am. J. Physiol. Heart Circ. Physiol. 278: H85–H93, 2000.—We tested the hypothesis that aged animals are as responsive as the young adult animals in expanding collateral vasculature under a similar treatment of basic fibroblast growth factor (bFGF). Two age groups of male Fischer 344 rats (1...

TLRs (Toll-like receptors) are the first line of defence of the innate immune system. These receptors recognize not only exogenous but also endogenous ligands that are expressed following arterial injury and atherosclerotic disease. Expression of TLR2 and TLR4 is observed in macrophages and different vascular cells and is increased in atherosclerotic disease. It is suggested that TLR expression...

Postpartum hemorrhage (PPH) is defined as a blood loss of more than 500 ml following vaginal delivery and more than 1 l following cesarean section. The definitive procedure for severe PPH is hysterectomy. Due to its high morbidity and impact on fertility, it is undesirable in majority of patients. Fertility preserving procedures include internal iliac artery ligation (IIAL), uterine artery liga...